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2.A.29.2.2
Dicarboxylate (succinate/fumarate/ malate/α-ketoglutarate/ oxaloacetate) antiporter

Accession Number:O89035
Protein Name:Mitochondrial dicarboxylate carrier
Length:286
Molecular Weight:31455.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate Succinate, Fumarate, malate, Alpha-ketoglutarate, Oxaloacetate

Cross database links:

Genevestigator: O89035
eggNOG: roNOG15732
RefSeq: NP_596909.1   
Entrez Gene ID: 170943   
Pfam: PF00153   
KEGG: rno:170943   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015297 F:antiporter activity
GO:0005488 F:binding
GO:0015140 F:malate transmembrane transporter activity
GO:0015114 F:phosphate transmembrane transporter activity
GO:0015141 F:succinate transmembrane transporter activity
GO:0015116 F:sulfate transmembrane transporter activity
GO:0015117 F:thiosulfate transmembrane transporter activity
GO:0015743 P:malate transport
GO:0006839 P:mitochondrial transport
GO:0006817 P:phosphate transport
GO:0015744 P:succinate transport
GO:0008272 P:sulfate transport
GO:0015709 P:thiosulfate transport
GO:0055085 P:transmembrane transport

References (4)

[1] “Identification by bacterial expression and functional reconstitution of the yeast genomic sequence encoding the mitochondrial dicarboxylate carrier protein.”  Palmieri L.et.al.   8985166
[2] “The sequence, bacterial expression, and functional reconstitution of the rat mitochondrial dicarboxylate transporter cloned via distant homologs in yeast and Caenorhabditis elegans.”  Fiermonte G.et.al.   9733776
[3] “Gene and alternative splicing annotation with AIR.”  Florea L.et.al.   15632090
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAEARTSRWY FGGLASCGAA CCTHPLDLLK VHLQTQQEVK LRMTGMALQV VRTDGFLALY 
61:	NGLSASLCRQ MTYSLTRFAI YETMRDYMTK DSQGPLPFYS KVLLGGISGL TGGFVGTPAD 
121:	LVNVRMQNDM KLPLSQRRNY SHALDGLYRV AREEGLKKLF SGATMASSRG ALVTVGQLSC 
181:	YDQAKQLVLS TGYLSDNIFT HFLSSFIAGG CATFLCQPLD VLKTRLMNSK GEYQGVFHCA 
241:	VETAKLGPQA FFKGLVPAGV RLVPHTVLTF MFLEQLRKHF GIKVAT