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2.A.29.2.3
Dicarboxylate:Pi antiporter (Pi, malate, succinate, oxaloacetate, sulfate, sulfite)

Accession Number:Q06143
Protein Name:DIC1 aka L8300.2 aka YLR348C
Length:298
Molecular Weight:32992.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate phosphate, malate, Succinate, Oxaloacetate, Sulfate, Sulfite

Cross database links:

Genevestigator: Q06143
eggNOG: fuNOG04025
HEGENOM: HBG735918
DIP: DIP-8816N
RefSeq: NP_013452.1   
Entrez Gene ID: 851063   
Pfam: PF00153   
KEGG: sce:YLR348C   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0015297 F:antiporter activity
GO:0005488 F:binding
GO:0005310 F:dicarboxylic acid transmembrane transporter...
GO:0006835 P:dicarboxylic acid transport
GO:0006817 P:phosphate transport
GO:0055085 P:transmembrane transport

References (10)

[1] “Identification of a novel gene encoding the yeast mitochondrial dicarboxylate transport protein via overexpression, purification, and characterization of its protein product.”  Kakhniashvili D.et.al.   9020177
[2] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.”  Johnston M.et.al.   9169871
[3] “Characterization, purification and properties of the yeast mitochondrial dicarboxylate carrier (Saccharomyces cerevisiae).”  Lancar-Benba J.et.al.   8831951
[4] “Bacterial overexpression of putative yeast mitochondrial transport proteins.”  Mayor J.A.et.al.   9559855
[5] “The mitochondrial dicarboxylate carrier is essential for the growth of Saccharomyces cerevisiae on ethanol or acetate as the sole carbon source.”  Palmieri L.et.al.   10027973
[6] “Biogenesis of the dicarboxylate carrier (DIC): translocation across the mitochondrial outer membrane and subsequent release from the TOM channel are membrane potential-independent.”  Zara V.et.al.   11502005
[7] “Global analysis of protein localization in budding yeast.”  Huh W.-K.et.al.   14562095
[8] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
[9] “The proteome of Saccharomyces cerevisiae mitochondria.”  Sickmann A.et.al.   14576278
[10] “The carboxyl-terminal third of the dicarboxylate carrier is crucial for productive association with the inner membrane twin-pore translocase.”  Brandner K.et.al.   15591051

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSTNAKESAG KNIKYPWWYG GAAGIFATMV THPLDLAKVR LQAAPMPKPT LFRMLESILA 
61:	NEGVVGLYSG LSAAVLRQCT YTTVRFGAYD LLKENVIPRE QLTNMAYLLP CSMFSGAIGG 
121:	LAGNFADVVN IRMQNDSALE AAKRRNYKNA IDGVYKIYRY EGGLKTLFTG WKPNMVRGIL 
181:	MTASQVVTYD VFKNYLVTKL DFDASKNYTH LTASLLAGLV ATTVCSPADV MKTRIMNGSG 
241:	DHQPALKILA DAVRKEGPSF MFRGWLPSFT RLGPFTMLIF FAIEQLKKHR VGMPKEDK