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2.A.29.2.4
Mammalian oxodicarboxylate carrier (ODC; SLC25A21; 607571) (transports C5-C7 oxodicarboxylates including 2-oxoadipate and 2-oxoglutarate in an antiport reaction; also transports less well: pimelate, 2-oxopimelate, 2-amino adipate, oxaloacetate, and citrate) (Defects cause 2-oxoadipate acidemia, an inborn error of metabolism)

Accession Number:Q9BQT8
Protein Name:Mitochondrial 2-oxodicarboxylate carrier
Length:299
Molecular Weight:33303.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate 2-oxoadipate, 2-oxoglutarate, Pimelate, 2-oxopimelate, 2-amino adipate, Oxaloacetate, Citrate

Cross database links:

Genevestigator: Q9BQT8 Q9BQT8 Q9BQT8
eggNOG: prNOG05969 NOG325140 NOG325140
HEGENOM: HBG735918 HOG000168307 HOG000168307
RefSeq: NP_001164641.1    NP_085134.1   
Entrez Gene ID: 89874   
Pfam: PF00153   
OMIM: 607571  gene
KEGG: hsa:89874    hsa:89874   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0015139 F:alpha-ketoglutarate transmembrane transport...
GO:0005488 F:binding
GO:0055085 P:transmembrane transport
GO:0006554 P:lysine catabolic process

References (8)

[1] “Identification of the human mitochondrial oxodicarboxylate carrier. Bacterial expression, reconstitution, functional characterization, tissue distribution and chromosomal location.”  Fiermonte G.et.al.   11083877
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Identification of the human mitochondrial oxodicarboxylate carrier. Bacterial expression, reconstitution, functional characterization, tissue distribution and chromosomal location.”  Fiermonte G.et.al.   11083877
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Initial characterization of the human central proteome.”  Burkard T.R.et.al.   21269460
[6] “Identification of the human mitochondrial oxodicarboxylate carrier. Bacterial expression, reconstitution, functional characterization, tissue distribution and chromosomal location.”  Fiermonte G.et.al.   11083877
[7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[8] “Initial characterization of the human central proteome.”  Burkard T.R.et.al.   21269460

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSAKPEVSLV REASRQIVAG GSAGLVEICL MHPLDVVKTR FQIQRCATDP NSYKSLVDSF 
61:	RMIFQMEGLF GFYKGILPPI LAETPKRAVK FFTFEQYKKL LGYVSLSPAL TFAIAGLGSG 
121:	LTEAIVVNPF EVVKVGLQAN RNTFAEQPST VGYARQIIKK EGWGLQGLNK GLTATLGRHG 
181:	VFNMVYFGFY YNVKNMIPVN KDPILEFWRK FGIGLLSGTI ASVINIPFDV AKSRIQGPQP 
241:	VPGEIKYRTC FKTMATVYQE EGILALYKGL LPKIMRLGPG GAVMLLVYEY TYSWLQENW