TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.29.2.6
Plant dicarboxylate/tricarboxylate carrier, DTC, transports dicarboxylates (such as malate, oxaloacetate, oxoglutarate, and maleate) and tricarboxylates (such as citrate, isocitrate, cis-aconitate, and trans-aconitate)

Accession Number:Q8SF04
Protein Name:DTC aka DTC1
Length:297
Molecular Weight:31681.00
Species:Nicotiana tabacum (Common tobacco) [4097]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate malate, Oxaloacetate, Oxoglutarate, Maleate, Citrate, Isocitrate, cis-aconitate, trans-aconitate

Cross database links:

Pfam: PF00153   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005739 C:mitochondrion
GO:0005488 F:binding
GO:0055085 P:transmembrane transport

References (1)

[1] “Identification of a novel transporter for dicarboxylates and tricarboxylates in plant mitochondria. Bacterial expression, reconstitution, functional characterization, and tissue distribution.”  Picault N.et.al.   11978797

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MGEKPKSGGV WPTVKPFVNG GASGMLATCV IQPIDMIKVR IQLGQGSAVD VTKTMLKNEG 
61:	FGAFYKGLSA GLLRQATYTT ARLGSFRSLT NKAIEANEGK PLPLYQKALC GLTAGAIGAC 
121:	VGSPADLALI RMQADATLPL AQRRHYTNAF HALSRIVADE GVLALWKGAG PTVVRAMALN 
181:	MGMLASYDQS VEFCRDNLGM SEAATVVGAS SVSGFFAAAC SLPFDYVKTQ IQKMQPDAEG 
241:	KLPYSGSFDC AMKTLKAGGP FKFYTGFPVY CVRIAPHVMM TWIFLNQIQK AEKKLGL