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2.A.29.2.7
Mitochondrial dicarboxylate carrier (DIC; SLC25A10; 606794) transports malate, succinate, phosphate, sulfate, thiosulfate

Accession Number:Q9UBX3
Protein Name:Mitochondrial dicarboxylate carrier
Length:287
Molecular Weight:31282.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate malate, Succinate, phosphate, Sulfate, Thiosulfate

Cross database links:

NOG300113NOG300113HOG000165139HOG000165139
Genevestigator: Q9UBX3 Q9UBX3 Q9UBX3
RefSeq: NP_036272.2   
Entrez Gene ID: 1468   
Pfam: PF00153   
Drugbank: Drugbank Link   
OMIM: 606794  gene
KEGG: hsa:1468    hsa:1468    hsa:1468   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005310 F:dicarboxylic acid transmembrane transporter...
GO:0005515 F:protein binding
GO:0006835 P:dicarboxylic acid transport
GO:0006094 P:gluconeogenesis
GO:0006839 P:mitochondrial transport
GO:0055085 P:transmembrane transport
GO:0005634 C:nucleus
GO:0005310 F:dicarboxylic acid transmembrane transporter activity
GO:0006811 P:ion transport
GO:0070221 P:sulfide oxidation, using sulfide:quinone oxidoreductase
GO:0000098 P:sulfur amino acid catabolic process

References (11)

[1] “Organization and sequence of the gene for the human mitochondrial dicarboxylate carrier: evolution of the carrier family.”  Fiermonte G.et.al.   10585886
[2] “Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.”  Otsuki T.et.al.   16303743
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Organization and sequence of the gene for the human mitochondrial dicarboxylate carrier: evolution of the carrier family.”  Fiermonte G.et.al.   10585886
[5] “Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.”  Otsuki T.et.al.   16303743
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “Initial characterization of the human central proteome.”  Burkard T.R.et.al.   21269460
[8] “Organization and sequence of the gene for the human mitochondrial dicarboxylate carrier: evolution of the carrier family.”  Fiermonte G.et.al.   10585886
[9] “Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.”  Otsuki T.et.al.   16303743
[10] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[11] “Initial characterization of the human central proteome.”  Burkard T.R.et.al.   21269460

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAAEARVSRW YFGGLASCGA ACCTHPLDLL KVHLQTQQEV KLRMTGMALR VVRTDGILAL 
61:	YSGLSASLCR QMTYSLTRFA IYETVRDRVA KGSQGPLPFH EKVLLGSVSG LAGGFVGTPA 
121:	DLVNVRMQND VKLPQGQRRN YAHALDGLYR VAREEGLRRL FSGATMASSR GALVTVGQLS 
181:	CYDQAKQLVL STGYLSDNIF THFVASFIAG GCATFLCQPL DVLKTRLMNS KGEYQGVFHC 
241:	AVETAKLGPL AFYKGLVPAG IRLIPHTVLT FVFLEQLRKN FGIKVPS