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2.A.29.2.8
2-oxodicarboxylate carrier 1 (ODC1) transports C5-C7 oxodicarboxylic acid (2-oxoadipate, 2-oxoglularate, adipate, glutarate, 2-oxopimelate, oxaloacetate, citrate and malate) (functions by a strict antiport mechanism (Palmieri et al., 2001).

Accession Number:Q03028
Protein Name:Mitochondrial 2-oxodicarboxylate carrier 1 ODC 1
Length:310
Molecular Weight:34206.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate 2-oxoadipate, 2-oxoglutarate, Adipate, Glutarate, 2-oxopimelate, Oxaloacetate, Citrate, malate

Cross database links:

Genevestigator: Q03028
eggNOG: fuNOG04756
HEGENOM: HBG735918
DIP: DIP-8776N
RefSeq: NP_015191.1   
Entrez Gene ID: 855969   
Pfam: PF00153   
KEGG: sce:YPL134C   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005488 F:binding
GO:0005310 F:dicarboxylic acid transmembrane transporter...
GO:0006839 P:mitochondrial transport
GO:0055085 P:transmembrane transport

References (3)

[1] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.”  Bussey H.et.al.   9169875
[2] “Identification in Saccharomyces cerevisiae of two isoforms of a novel mitochondrial transporter for 2-oxoadipate and 2-oxoglutarate.”  Palmieri L.et.al.   11013234
[3] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTSIDNRPLP FIYQFTAGAI AGVSELLVMY PLDVVKTRMQ LQVTTKGHPA VVAAKAAVDH 
61:	YTGVMDCLTK IVKKEGFSHL YKGITSPILM EAPKRAIKFS GNDTFQTFYK KIFPTPNGEM 
121:	TQKIAIYSGA SAGAVEAFVV APFELVKIRL QDVNSQFKTP IEVVKNSVVK GGVLSLFNGL 
181:	EATIWRHVLW NAGYFGIIFQ IRKLLPAAKT STEKTRNDLI AGAIGGTVGC LLNTPFDVVK 
241:	SRIQRSSGPL RKYNWSLPSV LLVYREEGFK ALYKGFAPKV MRLAPGGGLL LVVFTNVMDF 
301:	FREVKYGKKQ