TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.29.2.9
The dicarboxylate carriers, DIC1 (transports malate, oxaloacetate and succinate as well as phosphate, sulfate and thiosulfate at high rates: 2-oxoglutarate is a poor substrate (Palmieri et al., 2007)).

Accession Number:Q9SJY5
Protein Name:DIC1
Length:313
Molecular Weight:33357.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Location1 / Topology2 / Orientation3: Cell outer membrane1 / Multi-pass membrane protein2
Substrate malate, Oxaloacetate, Succinate, phosphate, Sulfate, Thiosulfate, 2-oxoglutarate

Cross database links:

Genevestigator: Q9SJY5
RefSeq: NP_179836.1   
Entrez Gene ID: 816783   
Pfam: PF00153   
KEGG: ath:AT2G22500   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005739 C:mitochondrion
GO:0005488 F:binding
GO:0005310 F:dicarboxylic acid transmembrane transporter...
GO:0006839 P:mitochondrial transport
GO:0055085 P:transmembrane transport

References (2)

[1] “Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.”  Lin X.et.al.   10617197
[2] “Molecular identification of three Arabidopsis thaliana mitochondrial dicarboxylate carrier isoforms: organ distribution, bacterial expression, reconstitution into liposomes and functional characterization.”  Palmieri L.et.al.   18039180

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MGLKGFAEGG IASIVAGCST HPLDLIKVRM QLQGESAPIQ TNLRPALAFQ TSTTVNAPPL 
61:	RVGVIGVGSR LIREEGMRAL FSGVSATVLR QTLYSTTRMG LYDIIKGEWT DPETKTMPLM 
121:	KKIGAGAIAG AIGAAVGNPA DVAMVRMQAD GRLPLTDRRN YKSVLDAITQ MIRGEGVTSL 
181:	WRGSSLTINR AMLVTSSQLA SYDSVKETIL EKGLLKDGLG THVSASFAAG FVASVASNPV 
241:	DVIKTRVMNM KVVAGVAPPY KGAVDCALKT VKAEGIMSLY KGFIPTVSRQ APFTVVLFVT 
301:	LEQVKKLFKD YDF