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2.A.29.20.1
Peroxisomal adenine nucleotide carrier, PMP34 (ANC; SLC25A17).  Probably specific for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extend for nicotinamide adenine dinucleotide (NAD+), adenosine diphosphate (ADP) and adenosine 3',5'-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD+ from the cytosol into the peroxisomal matrix by a counter-exchange mechanism. Inhibited by pyridoxal 5'-phosphate and bathophenanthroline in vitro (Visser et al. 2002; Agrimi et al. 2012).

Accession Number:O43808
Protein Name:Peroxisomal membrane protein PMP34 aka 34 kDa peroxisomal membrane protein aka Solute carrier family 25, member 17
Length:307
Molecular Weight:34567.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Peroxisome membrane1 / Multi-pass membrane protein2
Substrate Coenzyme A, FAD, FMN, AMP, NAD+, ADP, PAP

Cross database links:

Genevestigator: O43808 O43808
eggNOG: prNOG14268 NOG258628
HEGENOM: HBG735918 HOG000159426
RefSeq: NP_006349.1   
Entrez Gene ID: 10478   
Pfam: PF00153   
OMIM: 606795  gene
KEGG: hsa:10478    hsa:10478   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005778 C:peroxisomal membrane
GO:0005515 F:protein binding
GO:0005215 F:transporter activity
GO:0055085 P:transmembrane transport
GO:0005779 C:integral to peroxisomal membrane
GO:0005739 C:mitochondrion
GO:0015217 F:ADP transmembrane transporter activity
GO:0080122 F:AMP transmembrane transporter activity
GO:0005347 F:ATP transmembrane transporter activity
GO:0015228 F:coenzyme A transmembrane transporter activity
GO:0015230 F:FAD transmembrane transporter activity
GO:0051724 F:NAD transporter activity
GO:0001561 P:fatty acid alpha-oxidation
GO:0006635 P:fatty acid beta-oxidation
GO:0015908 P:fatty acid transport

References (20)

[1] “Identification and characterization of human PMP34, a protein closely related to the peroxisomal integral membrane protein PMP47 of Candida boidinii.”  Wylin T.et.al.   9874197
[2] “A genome annotation-driven approach to cloning the human ORFeome.”  Collins J.E.et.al.   15461802
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The DNA sequence of human chromosome 22.”  Dunham I.et.al.   10591208
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis.”  Sacksteder K.A.et.al.   10704444
[7] “Topogenesis of peroxisomal membrane protein requires a short, positively charged intervening-loop sequence and flanking hydrophobic segments: study using human membrane protein PMP34.”  Honsho M.et.al.   11121399
[8] “PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins.”  Jones J.M.et.al.   14709540
[9] “Identification and characterization of human PMP34, a protein closely related to the peroxisomal integral membrane protein PMP47 of Candida boidinii.”  Wylin T.et.al.   9874197
[10] “A genome annotation-driven approach to cloning the human ORFeome.”  Collins J.E.et.al.   15461802
[11] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[12] “The DNA sequence of human chromosome 22.”  Dunham I.et.al.   10591208
[13] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[14] “PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis.”  Sacksteder K.A.et.al.   10704444
[15] “Topogenesis of peroxisomal membrane protein requires a short, positively charged intervening-loop sequence and flanking hydrophobic segments: study using human membrane protein PMP34.”  Honsho M.et.al.   11121399
[16] “Multiple distinct targeting signals in integral peroxisomal membrane proteins.”  Jones J.M.et.al.   11402059
[17] “Identification of human PMP34 as a peroxisomal ATP transporter.”  Visser W.F.et.al.   12445829
[18] “PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins.”  Jones J.M.et.al.   14709540
[19] “The human gene SLC25A17 encodes a peroxisomal transporter of coenzyme A, FAD and NAD+.”  Agrimi G.et.al.   22185573
[20] “Initial characterization of the human central proteome.”  Burkard T.R.et.al.   21269460

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FASTA formatted sequence
1:	MASVLSYESL VHAVAGAVGS VTAMTVFFPL DTARLRLQVD EKRKSKTTHM VLLEIIKEEG 
61:	LLAPYRGWFP VISSLCCSNF VYFYTFNSLK ALWVKGQHST TGKDLVVGFV AGVVNVLLTT 
121:	PLWVVNTRLK LQGAKFRNED IVPTNYKGII DAFHQIIRDE GISALWNGTF PSLLLVFNPA 
181:	IQFMFYEGLK RQLLKKRMKL SSLDVFIIGA VAKAIATTVT YPLQTVQSIL RFGRHRLNPE 
241:	NRTLGSLRNI LYLLHQRVRR FGIMGLYKGL EAKLLQTVLT AALMFLVYEK LTAATFTVMG 
301:	LKRAHQH