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2.A.29.21.1
Mitochondrial GTP/GDP exchange carrier (Ggc1) [also transports deoxyGTP and deoxyGDP as well as ITP and IDP but less well than GTP and GDP] [KM(GTP)=1 μM; KM(GDP)=5 μM]. Inhibited by pyridoxal-5-P, bathophenanthroline and tannic acid but not by inhibitors of the ATP-ADP carrier (Vozza et al., 2004). GGC appears to be intrinsically plastic with structural plasticity asymmetrically distributed among the three homologous domains (Sounier et al. 2015).

Accession Number:P38988
Protein Name:GGc1p
Length:300
Molecular Weight:33215.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate GTP, GDP, DeoxyGTP, deoxyGDP, ITP, IDP

Cross database links:

Genevestigator: P38988
eggNOG: fuNOG04895
HEGENOM: HBG323910
DIP: DIP-7756N
RefSeq: NP_010083.1   
Entrez Gene ID: 851329   
Pfam: PF00153   
KEGG: sce:YDL198C   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0001409 F:guanine nucleotide transmembrane transporte...
GO:0005515 F:protein binding
GO:0006879 P:cellular iron ion homeostasis
GO:0001408 P:guanine nucleotide transport
GO:0000002 P:mitochondrial genome maintenance
GO:0055085 P:transmembrane transport

References (4)

[1] “SHM1: a multicopy suppressor of a temperature-sensitive null mutation in the HMG1-like abf2 gene.”  Kao L.-R.et.al.   8905928
[2] “The sequence of 23 kb surrounding the SNF3 locus on the left arm of yeast chromosome IV reveals the location of five known genes and characterizes at least six new open reading frames including putative genes for ribosomal protein L35 and a sugar transport protein.”  Verhasselt P.et.al.   8896272
[3] “The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.”  Jacq C.et.al.   9169867
[4] “Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.”  Hu Y.et.al.   17322287

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPHTDKKQSG LARLLGSASA GIMEIAVFHP VDTISKRLMS NHTKITSGQE LNRVIFRDHF 
61:	SEPLGKRLFT LFPGLGYAAS YKVLQRVYKY GGQPFANEFL NKHYKKDFDN LFGEKTGKAM 
121:	RSAAAGSLIG IGEIVLLPLD VLKIKRQTNP ESFKGRGFIK ILRDEGLFNL YRGWGWTAAR 
181:	NAPGSFALFG GNAFAKEYIL GLKDYSQATW SQNFISSIVG ACSSLIVSAP LDVIKTRIQN 
241:	RNFDNPESGL RIVKNTLKNE GVTAFFKGLT PKLLTTGPKL VFSFALAQSL IPRFDNLLSK