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2.A.29.23.2
Mg2+-ATP/Pi carrier, Sal1 (Ca2+ binding carrier, CMC1; supressor of AAC2 lethality (EF hand Ca2+ binding motif at N-terminus). ADP:ATP carrier 2 (Kucejova et al., 2008; Traba et al., 2008)

Accession Number:P48233
Protein Name:Suppressor of AAC2 lethality SAL1
Length:545
Molecular Weight:61270.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate Mg 2+, ATP, phosphate, ADP

Cross database links:

Genevestigator: P48233
eggNOG: fuNOG04788
HEGENOM: HBG735918
DIP: DIP-7616N
RefSeq: NP_014316.2   
Entrez Gene ID: 855641   
Pfam: PF00153   
KEGG: sce:YNL083W   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005471 F:ATP:ADP antiporter activity
GO:0005509 F:calcium ion binding
GO:0015866 P:ADP transport
GO:0015867 P:ATP transport
GO:0006839 P:mitochondrial transport
GO:0055085 P:transmembrane transport

References (10)

[1] “The yeast mitochondrial transport proteins: new sequences and consensus residues, lack of direct relation between consensus residues and transmembrane helices, expression patterns of the transport protein genes, and protein-protein interactions with other proteins.”  Belenkiy R.et.al.   10930523
[2] “Quantitative trait loci mapped to single-nucleotide resolution in yeast.”  Deutschbauer A.M.et.al.   16273108
[3] “The sequence of a 17,933 bp segment of Saccharomyces cerevisiae chromosome XIV contains the RHO2, TOP2, MKT1 and END3 genes and five new open reading frames.”  Soler-Mira A.et.al.   8740422
[4] “Sequencing a cosmid clone of Saccharomyces cerevisiae chromosome XIV reveals 12 new open reading frames (ORFs) and an ancient duplication of six ORFs.”  Poehlmann R.et.al.   8701611
[5] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications.”  Philippsen P.et.al.   9169873
[6] “Phylogenetic classification of the mitochondrial carrier family of Saccharomyces cerevisiae.”  el Moualij B.et.al.   9178508
[7] “Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii.”  Brachat S.et.al.   12844361
[8] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
[9] “Sal1p, a calcium-dependent carrier protein that suppresses an essential cellular function associated With the Aac2 isoform of ADP/ATP translocase in Saccharomyces cerevisiae.”  Chen X.J.et.al.   15238515
[10] “Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.”  Chi A.et.al.   17287358

External Searches:

  • Search: DB with
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  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLLKNCETDK QRDIRYACLF KELDVKGNGQ VTLDNLISAF EKNDHPLKGN DEAIKMLFTA 
61:	MDVNKDSVVD LSDFKKYASN AESQIWNGFQ RIDLDHDGKI GINEINRYLS DLDNQSICNN 
121:	ELNHELSNEK MNKFSRFFEW AFPKRKANIA LRGQASHKKN TDNDRSKKTT DSDLYVTYDQ 
181:	WRDFLLLVPR KQGSRLHTAY SYFYLFNEDV DLSSEGDVTL INDFIRGFGF FIAGGISGVI 
241:	SRTCTAPFDR LKVFLIARTD LSSILLNSKT DLLAKNPNAD INKISSPLAK AVKSLYRQGG 
301:	IKAFYVGNGL NVIKVFPESS IKFGSFEVTK KIMTKLEGCR DTKDLSKFST YIAGGLAGMA 
361:	AQFSVYPIDT LKFRVQCAPL DTKLKGNNLL FQTAKDMFRE GGLRLFYRGV TVGIVGIFPY 
421:	AALDLGTFSA LKKWYIAKQA KTLNLPQDQV TLSNLVVLPM GAFSGTVGAS VVYPINLLRT 
481:	RLQAQGTYAH PYVYNGFKDV LLKTLEREGY QGLFKGLVPT LAKVCPAVSI SYLCYENLKK 
541:	FMNLE