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2.A.29.23.7
solute carrier family 25, member 43.  May play a role in Paget's bone disease (Gutiérrez-Aguilar and Baines 2013).  Also regulates cell cycle progression and proliferation through a putative mitochondrial checkpoint (Gabrielson et al. 2015).

Accession Number:Q8WUT9
Protein Name:Solute carrier family 25 member 43
Length:341
Molecular Weight:37718.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate Unknown

Cross database links:

Genevestigator: Q8WUT9 Q8WUT9
eggNOG: NOG254584 NOG254584
HEGENOM: HOG000007857 HOG000007857
Entrez Gene ID: 203427   
Pfam: PF00153   
KEGG: hsa:203427    hsa:203427   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005488 F:binding
GO:0055085 P:transmembrane transport

References (8)

[1] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[2] “The DNA sequence of the human X chromosome.”  Ross M.T.et.al.   15772651
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system.”  Haitina T.et.al.   16949250
[5] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[6] “The DNA sequence of the human X chromosome.”  Ross M.T.et.al.   15772651
[7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[8] “Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system.”  Haitina T.et.al.   16949250

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MATWRRDGRL TGGQRLLCAG LAGTLSLSLT APLELATVLA QVGVVRGHAR GPWATGHRVW 
61:	RAEGLRALWK GNAVACLRLF PCSAVQLAAY RKFVVLFTDD LGHISQWSSI MAGSLAGMVS 
121:	TIVTYPTDLI KTRLIMQNIL EPSYRGLLHA FSTIYQQEGF LALYRGVSLT VVGALPFSAG 
181:	SLLVYMNLEK IWNGPRDQFS LPQNFANVCL AAAVTQTLSF PFETVKRKMQ AQSPYLPHSG 
241:	GVDVHFSGAV DCFRQIVKAQ GVLGLWNGLT ANLLKIVPYF GIMFSTFEFC KRICLYQNGY 
301:	ILSPLSYKLT PGVDQSLQPQ ELRELKKFFK TRKPKPKKPT L