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2.A.29.23.8
Calcium-binding mitochondrial carrier protein SCaMC-1 (Mitochondrial ATP-Mg/Pi carrier protein 1; Mitochondrial Ca2+-dependent solute carrier protein 1; Small calcium-binding mitochondrial carrier protein 1; Solute carrier family 25 member 24).  The crystal structure of the N-terminal Ca2+-binding domain has been determined and shown to undergo a large conformational change when Ca2+ binds (Yang et al. 2014).

Accession Number:Q6NUK1
Protein Name:Calcium-binding mitochondrial carrier protein SCaMC-1
Length:477
Molecular Weight:53354.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate ATP, Mg 2+, phosphate

Cross database links:

Genevestigator: Q6NUK1
eggNOG: NOG316894
Entrez Gene ID: 29957   
Pfam: PF00153   
KEGG: hsa:29957   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005739 C:mitochondrion
GO:0005509 F:calcium ion binding
GO:0055085 P:transmembrane transport

References (7)

[1] “Identification of a novel human subfamily of mitochondrial carriers with calcium-binding domains.”  del Arco A.et.al.   15054102
[2] “Identification of the mitochondrial ATP-Mg/Pi transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution.”  Fiermonte G.et.al.   15123600
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The DNA sequence and biological annotation of human chromosome 1.”  Gregory S.G.et.al.   16710414
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “Lysine acetylation targets protein complexes and co-regulates major cellular functions.”  Choudhary C.et.al.   19608861
[7] “Initial characterization of the human central proteome.”  Burkard T.R.et.al.   21269460
Structure:
4N5X   4ZCU   4ZCV     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLRWLRDFVL PTAACQDAEQ PTRYETLFQA LDRNGDGVVD IGELQEGLRN LGIPLGQDAE 
61:	EKIFTTGDVN KDGKLDFEEF MKYLKDHEKK MKLAFKSLDK NNDGKIEASE IVQSLQTLGL 
121:	TISEQQAELI LQSIDVDGTM TVDWNEWRDY FLFNPVTDIE EIIRFWKHST GIDIGDSLTI 
181:	PDEFTEDEKK SGQWWRQLLA GGIAGAVSRT STAPLDRLKI MMQVHGSKSD KMNIFGGFRQ 
241:	MVKEGGIRSL WRGNGTNVIK IAPETAVKFW AYEQYKKLLT EEGQKIGTFE RFISGSMAGA 
301:	TAQTFIYPME VMKTRLAVGK TGQYSGIYDC AKKILKHEGL GAFYKGYVPN LLGIIPYAGI 
361:	DLAVYELLKS YWLDNFAKDS VNPGVMVLLG CGALSSTCGQ LASYPLALVR TRMQAQAMLE 
421:	GSPQLNMVGL FRRIISKEGI PGLYRGITPN FMKVLPAVGI SYVVYENMKQ TLGVTQK