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2.A.29.24.3
solute carrier family 25, member 27; UCP4.  Transports protons and chloride ions; activated by fatty acids and inhibited by purine nucleotides similarly to UCP1-3 (Hoang et al. 2012).  H+ transport may be activated while Cl- transport may be inhibited by fatty acids (Hoang et al. 2015).

Accession Number:O95847
Protein Name:Mitochondrial uncoupling protein 4
Length:323
Molecular Weight:36064.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate H+, Cl-

Cross database links:

Genevestigator: O95847 O95847
eggNOG: NOG240642 NOG240642
HEGENOM: HOG000165140 HOG000165140
Entrez Gene ID: 9481   
Pfam: PF00153   
KEGG: hsa:9481    hsa:9481   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0006091 P:generation of precursor metabolites and energy
GO:0006810 P:transport

References (4)

[1] “UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells.”  Mao W.et.al.   10025957
[2] “The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.”  Clark H.F.et.al.   12975309
[3] “UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells.”  Mao W.et.al.   10025957
[4] “The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.”  Clark H.F.et.al.   12975309

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSVPEEEERL LPLTQRWPRA SKFLLSGCAA TVAELATFPL DLTKTRLQMQ GEAALARLGD 
61:	GARESAPYRG MVRTALGIIE EEGFLKLWQG VTPAIYRHVV YSGGRMVTYE HLREVVFGKS 
121:	EDEHYPLWKS VIGGMMAGVI GQFLANPTDL VKVQMQMEGK RKLEGKPLRF RGVHHAFAKI 
181:	LAEGGIRGLW AGWVPNIQRA ALVNMGDLTT YDTVKHYLVL NTPLEDNIMT HGLSSLCSGL 
241:	VASILGTPAD VIKSRIMNQP RDKQGRGLLY KSSTDCLIQA VQGEGFMSLY KGFLPSWLRM 
301:	TPWSMVFWLT YEKIREMSGV SPF