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2.A.29.3.1
Uncoupling protein (H+; halide anions; protonated or anionic fatty acids)

Accession Number:P10861
Protein Name:UCP1 aka UCP
Length:288
Molecular Weight:31143.00
Species:Bos taurus (Bovine) [9913]
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate H+, Halides, fatty acids

Cross database links:

eggNOG: maNOG15972
Pfam: PF00153   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005488 F:binding
GO:0006839 P:mitochondrial transport
GO:0055085 P:transmembrane transport

References (1)

[1] “Nucleotide sequence of a cDNA encoding bovine brown fat uncoupling protein. Homology with ADP binding site of ADP/ATP carrier.”  Casteilla L.et.al.   2928121

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	IFSAGVAACV ADIITFPLDT AKVRLQIQGE CLISSAIRYK GVLGTIITLA KTEGPVKLYS 
61:	GLPAGLQRQI SLASLRIGLY DTVQEFFTTG KEASLGSKIS AGLMTGGVAV FIGQPTEVVK 
121:	VRLQAQSHLH GPKPRYTGTY NAYRIIATTE GLTGLWKGTS PNLTTNVIIN CTELVTYDLM 
181:	KEALVKNKLL ADDVPCHFVS AVVAGFCTTV LSSPVDVVKT RFVNSSPGQN TSVPNCAMMM 
241:	LTREGPSAFF KGFVPSFLRL GSWNIMFVCF ERLKQELMKC RHTMDCAT