TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.29.3.2
Mitochondrial brown fat uncoupling protein 1 (UCP1) (thermogenin); obesity protein (SLC25A7); mediates adaptive thermogenesis Azzu and Brand, 2009).  Transports protons and chloride ions; activated by fatty acids and inhibited by purine nucleotides (Hoang et al. 2012).  Functions as a long-chain fatty acid (LCFA) anion/H+ symporter, but the LCFA anion can don dissociatedue to hydrophobic interactions, so it is, in effect, an H+ carrier (Fedorenko et al. 2012).  Thermogenic Brown adipose tissue cells with increased UCP1 activity also have increased ATP sythase activity to allow maintenance of normal ATP levels (Guillen et al. 2013).

Accession Number:P25874
Protein Name:Mitochondrial brown fat uncoupling protein 1 (UCP1) (thermogenin) aka obesity protein (SLC25A7)
Length:307
Molecular Weight:33005.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate H+, Cl-, fatty acids

Cross database links:

Genevestigator: P25874 P25874
eggNOG: prNOG12781 NOG277477
HEGENOM: HBG735918 HOG000165140
RefSeq: NP_068605.1   
Entrez Gene ID: 7350   
Pfam: PF00153   
OMIM: 113730  gene
KEGG: hsa:7350    hsa:7350   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0050873 P:brown fat cell differentiation
GO:0006839 P:mitochondrial transport
GO:0015992 P:proton transport
GO:0055085 P:transmembrane transport
GO:0017077 F:oxidative phosphorylation uncoupler activity
GO:0032870 P:cellular response to hormone stimulus
GO:0006357 P:regulation of transcription from RNA polymerase II promoter
GO:0022904 P:respiratory electron transport chain
GO:0048545 P:response to steroid hormone stimulus
GO:0044281 P:small molecule metabolic process

References (12)

[1] “Human uncoupling protein gene: structure, comparison with rat gene, and assignment to the long arm of chromosome 4.”  Cassard A.M.et.al.   2380264
[2] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”  Hillier L.W.et.al.   15815621
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Detection of brown adipose tissue uncoupling protein mRNA in adult patients by a human genomic probe.”  Bouillaud F.et.al.   3165741
[5] “A polymorphism in the 5' untranslated region and a Met229-->Leu variant in exon 5 of the human UCP1 gene are associated with susceptibility to type II diabetes mellitus.”  Mori H.et.al.   11317671
[6] “Uncoupling protein 1 and 3 polymorphisms are associated with waist-to-hip ratio.”  Herrmann S.M.et.al.   12756473
[7] “Human uncoupling protein gene: structure, comparison with rat gene, and assignment to the long arm of chromosome 4.”  Cassard A.M.et.al.   2380264
[8] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”  Hillier L.W.et.al.   15815621
[9] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[10] “Detection of brown adipose tissue uncoupling protein mRNA in adult patients by a human genomic probe.”  Bouillaud F.et.al.   3165741
[11] “A polymorphism in the 5' untranslated region and a Met229-->Leu variant in exon 5 of the human UCP1 gene are associated with susceptibility to type II diabetes mellitus.”  Mori H.et.al.   11317671
[12] “Uncoupling protein 1 and 3 polymorphisms are associated with waist-to-hip ratio.”  Herrmann S.M.et.al.   12756473

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MGGLTASDVH PTLGVQLFSA GIAACLADVI TFPLDTAKVR LQVQGECPTS SVIRYKGVLG 
61:	TITAVVKTEG RMKLYSGLPA GLQRQISSAS LRIGLYDTVQ EFLTAGKETA PSLGSKILAG 
121:	LTTGGVAVFI GQPTEVVKVR LQAQSHLHGI KPRYTGTYNA YRIIATTEGL TGLWKGTTPN 
181:	LMRSVIINCT ELVTYDLMKE AFVKNNILAD DVPCHLVSAL IAGFCATAMS SPVDVVKTRF 
241:	INSPPGQYKS VPNCAMKVFT NEGPTAFFKG LVPSFLRLGS WNVIMFVCFE QLKRELSKSR 
301:	QTMDCAT