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2.A.29.3.4
Human UCP2; implicated in a variety of physiological and pathological processes including protection from oxidative stress, negative regulation of glucose sensing systems and the adaptation of fatty acid oxidation capacity to starvation. Not involved in thermogenesis as is UCP1 (Azzu and Brand, 2009). Leucine zipper EF hand-containing transmembrane protein 1 (LetM1; 2.A.97) and uncoupling proteins 2 and 3 (UCP2/3) contribute to two distinct mitochondrial Ca2+ uptake pathways (Waldeck-Weiermair et al., 2011).  Transports protons and chloride ions; activated by fatty acids and inhibited by purine nucleotides (Hoang et al. 2012).  Reduces mitochondrial Ca2+ uptake in response to intracellular Ca2+ release in pancreatic beta cells (Alam et al. 2012).  Arginine residues in TMS2 are important for chloride transport without affecting fatty acid-dependent proton transport (Hoang et al. 2015).

Accession Number:P55851
Protein Name:Mitochondrial uncoupling protein 2
Length:309
Molecular Weight:33229.00
Species:homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate H+, Cl-

Cross database links:

Genevestigator: P55851 P55851
eggNOG: prNOG04053 NOG300436
HEGENOM: HBG735918 HOG000165140
RefSeq: NP_003346.2   
Entrez Gene ID: 7351   
Pfam: PF00153   
OMIM: 601693  gene
607447  phenotype
KEGG: hsa:7351    hsa:7351   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005488 F:binding
GO:0006839 P:mitochondrial transport
GO:0015992 P:proton transport
GO:0055085 P:transmembrane transport
GO:0032869 P:cellular response to insulin stimulus
GO:0022904 P:respiratory electron transport chain
GO:0070542 P:response to fatty acid
GO:0009749 P:response to glucose stimulus
GO:0001666 P:response to hypoxia
GO:0000303 P:response to superoxide
GO:0044281 P:small molecule metabolic process

References (14)

[1] “Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression.”  Boss O.et.al.   9180264
[2] “Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia.”  Fleury C.et.al.   9054939
[3] “Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis.”  Gimeno R.E.et.al.   9133562
[4] “Structure and organization of the human uncoupling protein 2 gene and identification of a common biallelic variant in Caucasian and African-American subjects.”  Argyropoulos G.et.al.   9568704
[5] “Functional organization of the human uncoupling protein-2 gene, and juxtaposition to the uncoupling protein-3 gene.”  Pecqueur C.et.al.   10082652
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans.”  Esterbauer H.et.al.   11381268
[8] “Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression.”  Boss O.et.al.   9180264
[9] “Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia.”  Fleury C.et.al.   9054939
[10] “Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis.”  Gimeno R.E.et.al.   9133562
[11] “Structure and organization of the human uncoupling protein 2 gene and identification of a common biallelic variant in Caucasian and African-American subjects.”  Argyropoulos G.et.al.   9568704
[12] “Functional organization of the human uncoupling protein-2 gene, and juxtaposition to the uncoupling protein-3 gene.”  Pecqueur C.et.al.   10082652
[13] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[14] “A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans.”  Esterbauer H.et.al.   11381268
Structure:
2lck     

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FASTA formatted sequence
1:	MVGFKATDVP PTATVKFLGA GTAACIADLI TFPLDTAKVR LQIQGESQGP VRATASAQYR 
61:	GVMGTILTMV RTEGPRSLYN GLVAGLQRQM SFASVRIGLY DSVKQFYTKG SEHASIGSRL 
121:	LAGSTTGALA VAVAQPTDVV KVRFQAQARA GGGRRYQSTV NAYKTIAREE GFRGLWKGTS 
181:	PNVARNAIVN CAELVTYDLI KDALLKANLM TDDLPCHFTS AFGAGFCTTV IASPVDVVKT 
241:	RYMNSALGQY SSAGHCALTM LQKEGPRAFY KGFMPSFLRL GSWNVVMFVT YEQLKRALMA 
301:	ACTSREAPF