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2.A.29.3.5
Human UCP3; implicated in a variety of physiological and pathological processes including protection from oxidative stress, negative regulation of glucose sensing systems and the adaptation of fatty acid oxidation capacity to starving. Not involved in thermogenesis as is UCP1 (Azzu and Brand, 2009). It also modulates the activity of the sarco/endoplasmic reticulum Ca2 -ATPase (SERCA) by decreasing mitochondrial ATP production (De Marchi et al., 2011). Leucine zipper EF hand-containing transmembrane protein 1 (LetM1; 2.A.97) and uncoupling proteins 2 and 3 (UCP2/3) contribute to two distinct mitochondrial Ca2 uptake pathways (Waldeck-Weiermair et al., 2011).  Transports protons and chloride ions; activated by fatty acids and inhibited by purine nucleotides (Hoang et al. 2012).

Accession Number:P55916
Protein Name:Mitochondrial uncoupling protein 3
Length:312
Molecular Weight:34216.00
Species:homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate H+, Cl-

Cross database links:

Genevestigator: P55916 P55916
eggNOG: prNOG06281 NOG300436
HEGENOM: HBG735918 HOG000165140
RefSeq: NP_003347.1    NP_073714.1   
Entrez Gene ID: 7352   
Pfam: PF00153   
OMIM: 601665  phenotype
602044  gene
KEGG: hsa:7352    hsa:7352   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005488 F:binding
GO:0006839 P:mitochondrial transport
GO:0015992 P:proton transport
GO:0007585 P:respiratory gaseous exchange
GO:0055085 P:transmembrane transport
GO:0017077 F:oxidative phosphorylation uncoupler activity
GO:0005215 F:transporter activity
GO:0007568 P:aging
GO:0032870 P:cellular response to hormone stimulus
GO:0006631 P:fatty acid metabolic process
GO:0006629 P:lipid metabolic process
GO:0022904 P:respiratory electron transport chain
GO:0014823 P:response to activity
GO:0009409 P:response to cold
GO:0051384 P:response to glucocorticoid stimulus
GO:0001666 P:response to hypoxia
GO:0032868 P:response to insulin stimulus
GO:0007584 P:response to nutrient
GO:0000303 P:response to superoxide
GO:0044281 P:small molecule metabolic process

References (16)

[1] “Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression.”  Boss O.et.al.   9180264
[2] “The human uncoupling protein-3 gene. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts.”  Solanes G.et.al.   9325252
[3] “UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue.”  Vidal-Puig A.et.al.   9196039
[4] “Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin.”  Gong D.-W.et.al.   9305858
[5] “Organisation of the coding exons and mutational screening of the uncoupling protein 3 gene in subjects with juvenile-onset obesity.”  Urhammer S.A.et.al.   9498661
[6] “The uncoupling protein-3 gene is transcribed from tissue-specific promoters in humans but not in rodents.”  Esterbauer H.et.al.   10958796
[7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[8] “Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes.”  Argyropoulos G.et.al.   9769326
[9] “Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression.”  Boss O.et.al.   9180264
[10] “The human uncoupling protein-3 gene. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts.”  Solanes G.et.al.   9325252
[11] “UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue.”  Vidal-Puig A.et.al.   9196039
[12] “Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin.”  Gong D.-W.et.al.   9305858
[13] “Organisation of the coding exons and mutational screening of the uncoupling protein 3 gene in subjects with juvenile-onset obesity.”  Urhammer S.A.et.al.   9498661
[14] “The uncoupling protein-3 gene is transcribed from tissue-specific promoters in humans but not in rodents.”  Esterbauer H.et.al.   10958796
[15] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[16] “Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes.”  Argyropoulos G.et.al.   9769326

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FASTA formatted sequence
1:	MVGLKPSDVP PTMAVKFLGA GTAACFADLV TFPLDTAKVR LQIQGENQAV QTARLVQYRG 
61:	VLGTILTMVR TEGPCSPYNG LVAGLQRQMS FASIRIGLYD SVKQVYTPKG ADNSSLTTRI 
121:	LAGCTTGAMA VTCAQPTDVV KVRFQASIHL GPSRSDRKYS GTMDAYRTIA REEGVRGLWK 
181:	GTLPNIMRNA IVNCAEVVTY DILKEKLLDY HLLTDNFPCH FVSAFGAGFC ATVVASPVDV 
241:	VKTRYMNSPP GQYFSPLDCM IKMVAQEGPT AFYKGFTPSF LRLGSWNVVM FVTYEQLKRA 
301:	LMKVQMLRES PF