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2.A.29.30.1
The human mitochondrial carrier (418aas; 6 TMSs) of unknown function (SLC25A46).  May play a role in atopic dermatitis (Gutiérrez-Aguilar and Baines 2013).

Accession Number:Q96AG3
Protein Name:Solute carrier family 25 member 46
Length:418
Molecular Weight:46174.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate Unknown

Cross database links:

HOG000007981
Genevestigator: Q96AG3 Q96AG3
eggNOG: prNOG09049 NOG237316
Entrez Gene ID: 91137   
Pfam: PF00153   
KEGG: hsa:91137    hsa:91137   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005488 F:binding
GO:0055085 P:transmembrane transport
GO:0006810 P:transport

References (12)

[1] “Identification of FAP locus genes from chromosome 5q21.”  Kinzler K.W.et.al.   1651562
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system.”  Haitina T.et.al.   16949250
[5] “Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.”  Daub H.et.al.   18691976
[6] “A quantitative atlas of mitotic phosphorylation.”  Dephoure N.et.al.   18669648
[7] “Identification of FAP locus genes from chromosome 5q21.”  Kinzler K.W.et.al.   1651562
[8] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[9] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[10] “Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system.”  Haitina T.et.al.   16949250
[11] “Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.”  Daub H.et.al.   18691976
[12] “A quantitative atlas of mitotic phosphorylation.”  Dephoure N.et.al.   18669648

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MHPRRPDGFD GLGYRGGARD EQGFGGAFPA RSFSTGSDLG HWVTTPPDIP GSRNLHWGEK 
61:	SPPYGVPTTS TPYEGPTEEP FSSGGGGSVQ GQSSEQLNRF AGFGIGLASL FTENVLAHPC 
121:	IVLRRQCQVN YHAQHYHLTP FTVINIMYSF NKTQGPRALW KGMGSTFIVQ GVTLGAEGII 
181:	SEFTPLPREV LHKWSPKQIG EHLLLKSLTY VVAMPFYSAS LIETVQSEII RDNTGILECV 
241:	KEGIGRVIGM GVPHSKRLLP LLSLIFPTVL HGVLHYIISS VIQKFVLLIL KRKTYNSHLA 
301:	ESTSPVQSML DAYFPELIAN FAASLCSDVI LYPLETVLHR LHIQGTRTII DNTDLGYEVL 
361:	PINTQYEGMR DCINTIRQEE GVFGFYKGFG AVIIQYTLHA AVLQITKIIY STLLQNNI