TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.29.4.2
Phosphate carrier protein (PiC); mitochondrial precursor (PTP) (SLC25A3).  Variants lead to a failure of inorganic phosphate (Pi) transport across the mitochondrial membrane, loss of oxidative phosphorylation, and phenotypically varied cases of skeletal myopathy and cardiomyopathy (Bhoj et al. 2015).

Accession Number:Q00325
Protein Name:Phosphate carrier protein (PiC) aka mitochondrial precursor (PTP) (SLC25A3)
Length:362
Molecular Weight:40095.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate phosphate

Cross database links:

Genevestigator: Q00325 Q00325
eggNOG: prNOG15437 NOG265500
HEGENOM: HBG526109 HOG000164438
RefSeq: NP_002626.1    NP_005879.1    NP_998776.1   
Entrez Gene ID: 5250   
Pfam: PF00153   
OMIM: 600370  gene
610773  phenotype
KEGG: hsa:5250    hsa:5250   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005488 F:binding
GO:0015320 F:phosphate carrier activity
GO:0015293 F:symporter activity
GO:0006091 P:generation of precursor metabolites and energy
GO:0055085 P:transmembrane transport
GO:0015320 F:phosphate ion carrier activity

References (15)

[1] “The sequences of human and bovine genes of the phosphate carrier from mitochondria contain evidence of alternatively spliced forms.”  Dolce V.et.al.   8144629
[2] “Nucleotide sequence of a human heart cDNA encoding the mitochondrial phosphate carrier.”  Dolce V.et.al.   1777677
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Large-scale proteomics analysis of the human kinome.”  Oppermann F.S.et.al.   19369195
[6] “Lysine acetylation targets protein complexes and co-regulates major cellular functions.”  Choudhary C.et.al.   19608861
[7] “Mitochondrial phosphate-carrier deficiency: a novel disorder of oxidative phosphorylation.”  Mayr J.A.et.al.   17273968
[8] “The sequences of human and bovine genes of the phosphate carrier from mitochondria contain evidence of alternatively spliced forms.”  Dolce V.et.al.   8144629
[9] “Nucleotide sequence of a human heart cDNA encoding the mitochondrial phosphate carrier.”  Dolce V.et.al.   1777677
[10] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[11] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[12] “Large-scale proteomics analysis of the human kinome.”  Oppermann F.S.et.al.   19369195
[13] “Lysine acetylation targets protein complexes and co-regulates major cellular functions.”  Choudhary C.et.al.   19608861
[14] “Initial characterization of the human central proteome.”  Burkard T.R.et.al.   21269460
[15] “Mitochondrial phosphate-carrier deficiency: a novel disorder of oxidative phosphorylation.”  Mayr J.A.et.al.   17273968

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MFSSVAHLAR ANPFNTPHLQ LVHDGLGDLR SSSPGPTGQP RRPRNLAAAA VEEQYSCDYG 
61:	SGRFFILCGL GGIISCGTTH TALVPLDLVK CRMQVDPQKY KGIFNGFSVT LKEDGVRGLA 
121:	KGWAPTFLGY SMQGLCKFGF YEVFKVLYSN MLGEENTYLW RTSLYLAASA SAEFFADIAL 
181:	APMEAAKVRI QTQPGYANTL RDAAPKMYKE EGLKAFYKGV APLWMRQIPY TMMKFACFER 
241:	TVEALYKFVV PKPRSECSKP EQLVVTFVAG YIAGVFCAIV SHPADSVVSV LNKEKGSSAS 
301:	LVLKRLGFKG VWKGLFARII MIGTLTALQW FIYDSVKVYF RLPRPPPPEM PESLKKKLGL 
361:	TQ