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2.A.29.5.1
MRS3 iron (Fe2+) import carrier in the inner mitochondrial membrane; essential for erythroid iron utilization) (Mühlenhoff et al., 2003). Uptake is dependent on the pH gradient (Froschauer et al. 2009).

Accession Number:P10566
Protein Name:MRS3 aka YJL133W aka J0675
Length:314
Molecular Weight:34502.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate Fe2+

Cross database links:

Genevestigator: P10566
eggNOG: fuNOG05107
HEGENOM: HBG735918
DIP: DIP-8202N
RefSeq: NP_012402.1   
Entrez Gene ID: 853308   
Pfam: PF00153   
KEGG: sce:YJL133W   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005381 F:iron ion transmembrane transporter activity
GO:0005515 F:protein binding
GO:0048250 P:mitochondrial iron ion transport
GO:0006397 P:mRNA processing
GO:0008380 P:RNA splicing
GO:0055085 P:transmembrane transport

References (5)

[1] “Nuclear suppression of a mitochondrial RNA splice defect: nucleotide sequence and disruption of the MRS3 gene.”  Schmidt C.et.al.   2448588
[2] “MRS3 and MRS4, two suppressors of mtRNA splicing defects in yeast, are new members of the mitochondrial carrier family.”  Wiesenberger G.et.al.   1703236
[3] “Sequence analysis of a 40.7 kb segment from the left arm of yeast chromosome X reveals 14 known genes and 13 new open reading frames including homologues of genes clustered on the right arm of chromosome XI.”  Katsoulou C.et.al.   8813765
[4] “Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.”  Galibert F.et.al.   8641269
[5] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVENSSSNNS TRPIPAIPMD LPDYEALPTH APLYHQLIAG AFAGIMEHSV MFPIDALKTR 
61:	IQSANAKSLS AKNMLSQISH ISTSEGTLAL WKGVQSVILG AGPAHAVYFG TYEFCKKNLI 
121:	DSSDTQTHHP FKTAISGACA TTASDALMNP FDTIKQRIQL NTSASVWQTT KQIYQSEGLA 
181:	AFYYSYPTTL VMNIPFAAFN FVIYESSTKF LNPSNEYNPL IHCLCGSISG STCAAITTPL 
241:	DCIKTVLQIR GSQTVSLEIM RKADTFSKAA SAIYQVYGWK GFWRGWKPRI VANMPATAIS 
301:	WTAYECAKHF LMTY