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2.A.29.5.2
MRS4 iron (Fe2+) import carrier in the inner mitochondrial membrane; essential for erythroid iron utilization) (Mühlenhoff et al., 2003). Uptake is dependent on the pH gradient (Froschauer et al. 2009).

Accession Number:P23500
Protein Name:MRS4 aka YKR052C
Length:304
Molecular Weight:33307.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate Fe2+

Cross database links:

Genevestigator: P23500
eggNOG: fuNOG05107
HEGENOM: HBG735918
DIP: DIP-4751N
RefSeq: NP_012978.1   
Entrez Gene ID: 853926   
Pfam: PF00153   
KEGG: sce:YKR052C   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005488 F:binding
GO:0005381 F:iron ion transmembrane transporter activity
GO:0048250 P:mitochondrial iron ion transport
GO:0006397 P:mRNA processing
GO:0008380 P:RNA splicing
GO:0055085 P:transmembrane transport

References (3)

[1] “MRS3 and MRS4, two suppressors of mtRNA splicing defects in yeast, are new members of the mitochondrial carrier family.”  Wiesenberger G.et.al.   1703236
[2] “Complete DNA sequence of yeast chromosome XI.”  Dujon B.et.al.   8196765
[3] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNTSELSIAE EIDYEALPSH APLHSQLLAG AFAGIMEHSL MFPIDALKTR VQAAGLNKAA 
61:	STGMISQISK ISTMEGSMAL WKGVQSVILG AGPAHAVYFG TYEFCKARLI SPEDMQTHQP 
121:	MKTALSGTIA TIAADALMNP FDTVKQRLQL DTNLRVWNVT KQIYQNEGFA AFYYSYPTTL 
181:	AMNIPFAAFN FMIYESASKF FNPQNSYNPL IHCLCGGISG ATCAALTTPL DCIKTVLQVR 
241:	GSETVSIEIM KDANTFGRAS RAILEVHGWK GFWRGLKPRI VANIPATAIS WTAYECAKHF 
301:	LMKN