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2.A.29.5.3
Mitochondrial iron transporter, mitoferrin (Shaw et al., 2006). Essential for erythroid iron utilization (Froschauer et al. 2009). Mitochondrial iron import regulation occurs through differential turnover of mitoferrin 1 and mitoferrin 2 (Paradkar et al., 2009)

Accession Number:Q287T7
Protein Name:Mitoferrin-1
Length:332
Molecular Weight:36711.00
Species:Danio rerio (Zebrafish) (Brachydanio rerio) [7955]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate iron

Cross database links:

eggNOG: fiNOG09048
HEGENOM: HBG735918
RefSeq: NP_001035060.1   
Entrez Gene ID: 387000   
Pfam: PF00153   
KEGG: dre:387000   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005488 F:binding
GO:0005381 F:iron ion transmembrane transporter activity
GO:0035162 P:embryonic hemopoiesis
GO:0043249 P:erythrocyte maturation
GO:0048250 P:mitochondrial iron ion transport
GO:0055085 P:transmembrane transport

References (1)

[1] “Mitoferrin is essential for erythroid iron assimilation.”  Shaw G.C.et.al.   16511496

External Searches:

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  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MELRTDAVLA SLEMSEPVKN DEDYESLPAH ASLGTHMTAG AVAGILEHTV MYPVDSVKTR 
61:	MQSLQPDPKA QYRSVYGALK RIVRTEGLLR PLRGLNITVL GAGPAHALYF ACYERIKRSL 
121:	SDVIQNGGNS HIANGVAGSV ATVLHDAVMN PAEVVKQRMQ MYNSPYRSLY DCVLMVSRKE 
181:	GLAAFYRSYS TQLTMNIPFQ AVHFITYEFM QEHFNPHRQY RPETHIISGA AAGAVSAAVT 
241:	TPLDVCKTLL NTQENVALSS AHVSGHLSGM VNALRTVYRL GGVPAFFKGI QARVIYQMPS 
301:	TAIAWSVYEF FKYFLTQHES HVQEVSHKTS PT