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2.A.29.5.4
solute carrier family 25 (mitochondrial iron transporter), member 28, putative iron transporter; Mitoferrin-2

Accession Number:Q8R0Z5
Protein Name:Mitoferrin-2
Length:364
Molecular Weight:39358.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate iron

Cross database links:

Genevestigator: Q8R0Z5
eggNOG: NOG261622
HEGENOM: HOG000038810
Entrez Gene ID: 246696   
Pfam: PF00153   
KEGG: mmu:246696   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0006811 P:ion transport
GO:0055072 P:iron ion homeostasis

References (3)

[1] “Characterization of a novel human putative mitochondrial transporter homologous to the yeast mitochondrial RNA splicing proteins 3 and 4.”  Li F.-Y.et.al.   11297739
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Mitoferrin is essential for erythroid iron assimilation.”  Shaw G.C.et.al.   16511496

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MELEGRSAGG VAGGPAAGPG RSPGESALLD GWLQRGVGRG AGGGEAGAYQ PPVRLDPESG 
61:	PEYEALPAGA TVTTHMVAGA VAGILEHCVM YPIDCVKTRM QSLQPDPAAR YRNVLEALWR 
121:	IMRTEGLWRP MRGLNVTATG AGPAHALYFA CYEKLKKTLS DVIHPGGNSH IANGAAGCVA 
181:	TLLHDAAMNP AEVVKQRMQM YNSPYHRVTD CVRAVWQNEG AGAFYRSYTT QLTMNVPFQA 
241:	IHFMTYEFLQ EHFNPQRRYN PSSHVLCGAC AGAVAAAATT PLDVCKTLLN TQESLALNSN 
301:	ITGHITGMAS AFRTVYQVGG VTAYFRGVQA RVIYQIPSTA IAWSVYEFFK YLITKRQEEW 
361:	RAGK