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2.A.29.7.1
Tricarboxylate carrier (exchanges a tricarboxylate (citrate, isocitrate, cis-aconitate) + H+ for another tricarboxylate + H+, a dicarboxylate (malate, succinate) or phosphoenolpyruvate).

Accession Number:P32089
Protein Name:TXTP aka SLC25A1 aka SLC20A3
Length:311
Molecular Weight:33835.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate Citrate, Isocitrate, cis-aconitate, H+, malate, Succinate, Phosphoenolpyruvate

Cross database links:

Genevestigator: P32089
eggNOG: roNOG15150
RefSeq: NP_059003.1   
Entrez Gene ID: 29743   
Pfam: PF00153   
KEGG: rno:29743   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005488 F:binding
GO:0015137 F:citrate transmembrane transporter activity
GO:0006843 P:mitochondrial citrate transport
GO:0055085 P:transmembrane transport

References (2)

[1] “The mitochondrial tricarboxylate transport protein. cDNA cloning, primary structure, and comparison with other mitochondrial transport proteins.”  Kaplan R.S.et.al.   8514800
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAAPRAPRAL TAAAPGSGKA KLTHPGKAIL AGGLAGGIEI CITFPTEYVK TQLQLDERAN 
61:	PPRYRGIGDC VRQTVRSHGV LGLYRGLSSL LYGSIPKAAV RFGMFEFLSN HMRDAQGRLD 
121:	SRRGLLCGLG AGVAEAVVVV CPMETVKVKF IHDQTSSNPK YRGFFHGVRE IVREQGLKGT 
181:	YQGLTATVLK QGSNQAIRFF VMTSLRNWYQ GDNPNKPMNP LITGVFGAVA GAASVFGNTP 
241:	LDVIKTRMQG LEAHKYRNTL DCGVQILKNE GPKAFYKGTV PRLGRVCLDV AIVFVIYDEV 
301:	VKLLNKVWKT D