TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.29.7.3
Citrate transport protein, CTP1. Catalyzes obligatory exchange of the dibasic form of tricarboxylates (citrate and isocitrate) for other tricarboxylates. Two citrate binding sites per monomer have been identified (Ma et al., 2007). Mutations in residues in internal or external pore regions can relax the specificity, converting CTP1 into a nonspecific anion carrier. The data is consistent with outward-facing, occluded, and inward-facing states.

Accession Number:P38152
Protein Name:Citrate transport protein CTP1
Length:299
Molecular Weight:32173.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate Citrate, Isocitrate, Tricarboxylates

Cross database links:

Genevestigator: P38152
eggNOG: fuNOG05252
HEGENOM: HBG735918
DIP: DIP-5645N
RefSeq: NP_009850.1   
Entrez Gene ID: 852594   
Pfam: PF00153   
KEGG: sce:YBR291C   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005488 F:binding
GO:0005371 F:tricarboxylate secondary active transmembra...
GO:0006843 P:mitochondrial citrate transport
GO:0055085 P:transmembrane transport

References (3)

[1] “High level expression and characterization of the mitochondrial citrate transport protein from the yeast Saccharomyces cerevisiae.”  Kaplan R.S.et.al.   7876161
[2] “The sequence of a 32,420 bp segment located on the right arm of chromosome II from Saccharomyces cerevisiae.”  Holmstroem K.et.al.   8091861
[3] “Complete DNA sequence of yeast chromosome II.”  Feldmann H.et.al.   7813418

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MSSKATKSDV DPLHSFLAGS LAGAAEACIT YPFEFAKTRL QLIDKASKAS RNPLVLIYKT 
61:	AKTQGIGSIY VGCPAFIIGN TAKAGIRFLG FDTIKDMLRD SETGELSGTR GVIAGLGAGL 
121:	LESVAAVTPF EAIKTALIDD KQSATPKYHN NGRGVVRNYS SLVRDKGFSG LYRGVLPVSM 
181:	RQAANQAVRL GCYNKIKTLI QDYTDSPKDK PLSSGLTFLV GAFSGIVTVY STMPLDTVKT 
241:	RMQSLDSTKY SSTMNCFATI FKEEGLKTFW KGATPRLGRL VLSGGIVFTI YEKVLVMLA