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2.A.29.7.4
The fruit fly citrate uptake carrier, CIC (expressed at all stages of development; same substrate as for other eukaryotic tricarboxylate transporters (Carrisi et al., 2008).

Accession Number:Q7KSQ0
Protein Name:CG6782, isoform A
Length:317
Molecular Weight:34094.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Citrate

Cross database links:

eggNOG: inNOG09360
RefSeq: NP_001027175.1    NP_001027176.1    NP_001027177.1    NP_001027178.1   
Entrez Gene ID: 3772221   
Pfam: PF00153   
KEGG: dme:Dmel_CG6782   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005488 F:binding
GO:0005215 F:transporter activity
GO:0055085 P:transmembrane transport

References (2)

[1] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[2] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDRSAFASLV SPYRRRPWMT EHGAAAADSG QVGLKGIVAG GITGGIEICI TYPTEYVKTQ 
61:	LQLDEKGAAK KYNGIFDCVK KTVGERGFLG LYRGLSVLVY GSIPKSAARF GAFEFLKSNA 
121:	VDSRGQLSNS GKLLCGLGAG VCEAIVAVTP METIKVKFIN DQRSGNPKFR GFAHGVGQII 
181:	KSEGISGIYK GLTPTILKQG SNQAIRFFVL ESLKDLYKGD DHTKPVPKLV VGVFGAIAGA 
241:	ASVFGNTPLD VVKTRMQGLE ASKYKNTAHC AVEILKNEGP AAFYKGTVPR LGRVCLDVAI 
301:	TFMIYDSFMD LFNKVWV