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2.A.29.8.1
Mitochondrial carnitine/acyl carnitine carrier (CAC)

Accession Number:P97521
Protein Name:MCAT aka CAC aka SLC25A20 aka CACT
Length:301
Molecular Weight:33154.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate Carnitine, Acyl Carnitine

Cross database links:

Genevestigator: P97521
eggNOG: roNOG14961
Pfam: PF00153   
BioCyc: MetaCyc:MONOMER-14443   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005488 F:binding
GO:0005215 F:transporter activity
GO:0055085 P:transmembrane transport

References (1)

[1] “The mitochondrial carnitine carrier protein: cDNA cloning, primary structure and comparison with other mitochondrial transport proteins.”  Indiveri C.et.al.   9032458
Structure:
2BMN     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAEEPKPISP LKNLLAGGFG GVCLVFVGHP LDTVKVRLQT QPPSLPGQPP MYSGTIDCFR 
61:	KTLFREGITG LYRGMAAPII GVTPMFAVCF FGFGLGKRLQ QKSPEDELTY PQLFTAGMLS 
121:	GVFTTGIMTP GERIKCLLQI QASSGKNKYS GTLDCAKKLY QEFGIRGFYK GTALTLMRDV 
181:	PASGMYFMTY EWLKNLFTPQ GKSVHDLSVP RVLVAGGFRG IFNWVVAIPP DVLKSRFQTA 
241:	PPGKYPNGFR DVLRELIREE GVTSLYKGFN AVMIRAFPAN AACFLGFEIP MKILNWIAPN 
301:	L