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2.A.29.8.2
Embryonic differentiation (DIF-1) protein

Accession Number:Q27257
Protein Name:DIF-1 aka F49E8.5
Length:312
Molecular Weight:33135.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate Unknown

Cross database links:

eggNOG: meNOG04776
HEGENOM: HBG735918
RefSeq: NP_501223.1   
Entrez Gene ID: 177530   
Pfam: PF00153   
KEGG: cel:F49E8.5   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005488 F:binding
GO:0005215 F:transporter activity
GO:0009792 P:embryonic development ending in birth or eg...
GO:0006839 P:mitochondrial transport
GO:0055085 P:transmembrane transport

References (3)

[1] “Extension of the mitochondrial transporter super-family: sequences of five members from the nematode worm, Caenorhabditis elegans.”  Runswick M.J.et.al.   7803813
[2] “Embryonic tissue differentiation in Caenorhabditis elegans requires dif-1, a gene homologous to mitochondrial solute carriers.”  Ahringer J.et.al.   7774589
[3] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSDVLLNFIA GGVGGSCTVI VGHPFDTVKV RIQTMPMPKP GEKPQFTGAL DCVKRTVSKE 
61:	GFFALYKGMA APLVGVSPLF AVFFGGCAVG KWLQQTDPSQ EMTFIQNANA GALAGVFTTI 
121:	VMVPGERIKC LLQVQQAGSA GSGVHYDGPL DVVKKLYKQG GISSIYRGTG ATLLRDIPAS 
181:	AAYLSVYEYL KKKFSGEGAQ RTLSPGATLM AGGLAGIANW GVCIPADVLK SRLQTAPEGK 
241:	YPDGIRGVLR EVLREEGPRA LFKGFWPVML RAFPANAACF FGLELTLAAF RYFGIGGHPT 
301:	PSTEVVPLPH DE