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2.A.29.8.5
The carnitine:acylcarnitine exchange translocase, CACL. CACL is similar in tissue distribution to that of CACT (TC# 2.A.29.8.3); both are expressed at a higher level in tissues using fatty acids as fuels, except the brain, where only CACL is expressed (Sekoguchi et al., 2003)

Accession Number:Q8BL03
Protein Name:Mitochondrial carnitine/acylcarnitine carrier protein CACL
Length:306
Molecular Weight:32672.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate Acylcarnitine, Carnitine

Cross database links:

Genevestigator: Q8BL03 Q8BL03
eggNOG: roNOG15405 NOG285985
HEGENOM: HBG735918 HOG000168307
RefSeq: NP_851845.1   
Entrez Gene ID: 214663   
Pfam: PF00153   
KEGG: mmu:214663    mmu:214663   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0015227 F:acyl carnitine transporter activity
GO:0005488 F:binding
GO:0006844 P:acyl carnitine transport
GO:0055085 P:transmembrane transport

References (6)

[1] “A novel mitochondrial carnitine-acylcarnitine translocase induced by partial hepatectomy and fasting.”  Sekoguchi E.et.al.   12882971
[2] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “A novel mitochondrial carnitine-acylcarnitine translocase induced by partial hepatectomy and fasting.”  Sekoguchi E.et.al.   12882971
[5] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MALDFLAGCA GGVAGVIVGH PFDIVKVRLQ VQSTEKPQYR GTLHCFQSII KQESVLGLYK 
61:	GLGSPLMGLT FINALVFGVQ GNTLRALGQD SPLNQFLAGA AAGAIQCVIC CPMELAKTRL 
121:	QLQAVGPART YKGSLDCLVQ IYRHEGLRGI NRGMVSTLLR ETPSFGVYFL TYDVMTRAMG 
181:	CEPGDRLLVP KLLLAGGTSG ITSWLSTYPM DVVKSRLQAD GLQGTPRYRG IVDCMRQSYQ 
241:	AEGWQVFTRG LASTLLRAFP VNAATFATVT VVLTYTRGEE AQVDSEAALG TSPTPAGSAL 
301:	AQPSSL