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2.A.29.8.9
Mitochondrial carrier protein CACL (CACT-like) (Solute carrier family 25 member 29).  Transports basic amino acids (Porcelli et al. 2014).  It transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine. Carnitine and acylcarnitines were not transported by SLC25A29. This carrier catalyzes substantial uniport besides counter-exchange transport and exhibits a high transport affinity for arginine and lysine.  It is saturable and inhibited by mercurial compounds and other inhibitors of mitochondrial carriers to various degrees. The main physiological role of SLC25A29 is to import basic amino acids into mitochondria for mitochondrial protein synthesis and amino acid degradation (Porcelli et al. 2014).

Accession Number:Q8N8R3
Protein Name:Mitochondrial carnitine/acylcarnitine carrier protein CACL
Length:303
Molecular Weight:32062.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate Arginine, Homoarginine, Methylarginine, Ornithine, Histidine

Cross database links:

Genevestigator: Q8N8R3
eggNOG: NOG285985
HEGENOM: HOG000168307
Entrez Gene ID: 123096   
Pfam: PF00153   
Drugbank: Drugbank Link   
KEGG: hsa:123096   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0015227 F:acyl carnitine transporter activity

References (1)

[1] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MALDFLAGCA GGVAGVLVGH PFDTVKVRLQ VQSVEKPQYR GTLHCFKSII KQESVLGLYK 
61:	GLGSPLMGLT FINALVFGVQ GNTLRALGHD SPLNQFLAGA AAGAIQCVIC CPMELAKTRL 
121:	QLQDAGPART YKGSLDCLAQ IYGHEGLRGV NRGMVSTLLR ETPSFGVYFL TYDALTRALG 
181:	CEPGDRLLVP KLLLAGGTSG IVSWLSTYPV DVVKSRLQAD GLRGAPRYRG ILDCVHQSYR 
241:	AEGWRVFTRG LASTLLRAFP VNAATFATVT VVLTYARGEE AGPEGEAVPA APAGPALAQP 
301:	SSL