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2.A.3.1.3
Aromatic amino acid:H+ symporter, AroP of 457 aas and 12 TMSs (Cosgriff and Pittard 1997). Transports phenylalanine, tyrosine and tryptophan (Honoré and Cole 1990).

Accession Number:P15993
Protein Name:AroP aka B0112
Length:457
Molecular Weight:49690.00
Species:Escherichia coli [83333]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate tryptophan, tyrosine, phenylalanine

Cross database links:

Genevestigator: P15993
EchoBASE: EB0082
EcoGene: EG10084
eggNOG: COG1113
HEGENOM: HBG492579
RefSeq: AP_000773.1    NP_414654.1   
Entrez Gene ID: 946018   
Pfam: PF00324   
BioCyc: EcoCyc:AROP-MONOMER    ECOL168927:B0112-MONOMER   
KEGG: ecj:JW0108    eco:b0112   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015171 F:amino acid transmembrane transporter activity
GO:0006865 P:amino acid transport
GO:0055085 P:transmembrane transport

References (6)

[1] “Nucleotide sequence of the aroP gene encoding the general aromatic amino acid transport protein of Escherichia coli K-12: homology with yeast transport proteins.”  Honore N.et.al.   2408019
[2] “A topological model for the general aromatic amino acid permease, AroP, of Escherichia coli.”  Cosgriff A.J.et.al.   9150230
[3] “Systematic sequencing of the Escherichia coli genome: analysis of the 2.4-4.1 min (110,917-193,643 bp) region.”  Fujita N.et.al.   8202364
[4] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[5] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[6] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MMEGQQHGEQ LKRGLKNRHI QLIALGGAIG TGLFLGSASV IQSAGPGIIL GYAIAGFIAF 
61:	LIMRQLGEMV VEEPVAGSFS HFAYKYWGSF AGFASGWNYW VLYVLVAMAE LTAVGKYIQF 
121:	WYPEIPTWVS AAVFFVVINA INLTNVKVFG EMEFWFAIIK VIAVVAMIIF GGWLLFSGNG 
181:	GPQATVSNLW DQGGFLPHGF TGLVMMMAII MFSFGGLELV GITAAEADNP EQSIPKATNQ 
241:	VIYRILIFYI GSLAVLLSLM PWTRVTADTS PFVLIFHELG DTFVANALNI VVLTAALSVY 
301:	NSCVYCNSRM LFGLAQQGNA PKALASVDKR GVPVNTILVS ALVTALCVLI NYLAPESAFG 
361:	LLMALVVSAL VINWAMISLA HMKFRRAKQE QGVVTRFPAL LYPLGNWICL LFMAAVLVIM 
421:	LMTPGMAISV YLIPVWLIVL GIGYLFKEKT AKAVKAH