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2.A.3.1.4
γ-aminobutyrate:H+ symporter (also transports a variety of pyridine carboxylates)

Accession Number:P25527
Protein Name:GabP aka B2663
Length:466
Molecular Weight:51080.00
Species:Escherichia coli [83333]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Gamma-aminobutyrate, H+, GABA

Cross database links:

Genevestigator: P25527
EchoBASE: EB1306
EcoGene: EG11330
eggNOG: COG1113
HEGENOM: HBG492579
DIP: DIP-9724N
RefSeq: AP_003236.1    NP_417149.1   
Entrez Gene ID: 948049   
Pfam: PF00324   
BioCyc: EcoCyc:GABP-MONOMER    ECOL168927:B2663-MONOMER   
KEGG: ecj:JW2638    eco:b2663   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015185 F:L-gamma-aminobutyric acid transmembrane tra...
GO:0015812 P:gamma-aminobutyric acid transport
GO:0055085 P:transmembrane transport

References (5)

[1] “Molecular organization of the Escherichia coli gab cluster: nucleotide sequence of the structural genes gabD and gabP and expression of the GABA permease gene.”  Niegemann E.et.al.   8297211
[2] “Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features.”  Yamamoto Y.et.al.   9205837
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGQSSQPHEL GGGLKSRHVT MLSIAGVIGA SLFVGSSVAI AEAGPAVLLA YLFAGLLVVM 
61:	IMRMLAEMAV ATPDTGSFST YADKAIGRWA GYTIGWLYWW FWVLVIPLEA NIAAMILHSW 
121:	VPGIPIWLFS LVITLALTGS NLLSVKNYGE FEFWLALCKV IAILAFIFLG AVAISGFYPY 
181:	AEVSGISRLW DSGGFMPNGF GAVLSAMLIT MFSFMGAEIV TIAAAESDTP EKHIVRATNS 
241:	VIWRISIFYL CSIFVVVALI PWNMPGLKAV GSYRSVLELL NIPHAKLIMD CVILLSVTSC 
301:	LNSALYTASR MLYSLSRRGD APAVMGKINR SKTPYVAVLL STGAAFLTVV VNYYAPAKVF 
361:	KFLIDSSGAI ALLVYLVIAV SQLRMRKILR AEGSEIRLRM WLYPWLTWLV IGFITFVLVV 
421:	MLFRPAQQLE VISTGLLAIG IICTVPIMAR WKKLVLWQKT PVHNTR