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2.A.3.1.5
β-alanine/γ-aminobutyrate/proline/3,4-dehydroproline:H+ symporter, GabP (Ferson et al. 1996; Zaprasis et al. 2014).  Also transports 3-aminobutyrate, 3-aminopropanoate, cis-4-aminobutenoate (Brechtel and King 1998).

Accession Number:P46349
Protein Name:GabP
Length:469
Molecular Weight:51085.00
Species:Bacillus subtilis [1423]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate beta-alanine, Gamma-aminobutyrate, Proline, 3,4-dehydroproline, H+, 3-aminobutyrate, 3-aminopropanoate, cis-4-aminobutenoate

Cross database links:

HEGENOM: HBG492579
RefSeq: NP_388512.2   
Entrez Gene ID: 939485   
Pfam: PF00324   
KEGG: bsu:BSU06310   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015185 F:L-gamma-aminobutyric acid transmembrane tra...
GO:0015812 P:gamma-aminobutyric acid transport
GO:0055085 P:transmembrane transport

References (4)

[1] “Expression of the Bacillus subtilis gabP gene is regulated independently in response to nitrogen and amino acid availability.”  Ferson A.E.et.al.   8951816
[2] “The 52 degrees-55 degrees segment of the Bacillus subtilis chromosome: a region devoted to purine uptake and metabolism, and containing the genes cotA, gabP and guaA and the pur gene cluster within a 34960 bp nucleotide sequence.”  Borriss R.et.al.   8969499
[3] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377
[4] “From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later.”  Barbe V.et.al.   19383706

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNQSQSGLKK ELKTRHMTMI SIAGVIGAGL FVGSGSVIHS TGPGAVVSYA LAGLLVIFIM 
61:	RMLGEMSAVN PTSGSFSQYA HDAIGPWAGF TIGWLYWFFW VIVIAIEAIA GAGIIQYWFH 
121:	DIPLWLTSLI LTIVLTLTNV YSVKSFGEFE YWFSLIKVVT IIAFLIVGFA FIFGFAPGSE 
181:	PVGFSNLTGK GGFFPEGISS VLLGIVVVIF SFMGTEIVAI AAGETSNPIE SVTKATRSVV 
241:	WRIIVFYVGS IAIVVALLPW NSANILESPF VAVLEHIGVP AAAQIMNFIV LTAVLSCLNS 
301:	GLYTTSRMLY SLAERNEAPR RFMKLSKKGV PVQAIVAGTF FSYIAVVMNY FSPDTVFLFL 
361:	VNSSGAIALL VYLVIAVSQL KMRKKLEKTN PEALKIKMWL FPFLTYLTII AICGILVSMA 
421:	FIDSMRDELL LTGVITGIVL ISYLVFRKRK VSEKAAANPV TQQQPDILP