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2.A.3.1.6
Proline-specific permease (ProY)

Accession Number:P37460
Protein Name:ProY aka STM0400
Length:456
Molecular Weight:50048.00
Species:Salmonella typhimurium [90371]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Proline

Cross database links:

HEGENOM: HBG492579
RefSeq: NP_459395.1   
Entrez Gene ID: 1251919   
Pfam: PF00324   
BioCyc: STYP99287:STM0400-MONOMER   
KEGG: stm:STM0400   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015171 F:amino acid transmembrane transporter activity
GO:0006865 P:amino acid transport
GO:0055085 P:transmembrane transport

References (2)

[1] “A cryptic proline permease in Salmonella typhimurium.”  Liao M.K.et.al.   9308174
[2] “Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.”  McClelland M.et.al.   11677609

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MESNNKLKRG LSTRHIRFMA LGSAIGTGLF YGSADAIKMA GPSVLLAYII GGVAAYIIMR 
61:	ALGEMSVHNP AASSFSRYAQ ENLGPLAGYI TGWTYCFEIL IVAIADVTAF GIYMGVWFPA 
121:	VPHWIWVLSV VLIICAINLM SVKVFGELEF WFSFFKVATI IIMIVAGIGI IVWGIGNGGQ 
181:	PTGIHNLWSN GGFFSNGWLG MIMSLQMVMF AYGGIEIIGI TAGEAKDPEK SIPRAINSVP 
241:	MRILVFYVGT LFVIMSIYPW NQVGTNGSPF VLTFQHMGIT FAASILNFVV LTASLSAINS 
301:	DVFGVGRMLH GMAEQGSAPK VFAKTSRRGI PWVTVLVMTI ALLFAVYLNY IMPENVFLVI 
361:	ASLATFATVW VWIMILLSQI AFRRRLPPEE VKALKFKVPG GVVTTIAGLI FLVFIIALIG 
421:	YHPDTRISLY VGFAWIVLLL IGWIFKRRRD RQLAQA