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2.A.3.10.1
High affinity histidine permease (also implicated in Mn2+ efflux; Co2+, Ni2+, Zn2+ and Cu2+ uptake)

Accession Number:P06775
Protein Name:Hip1 aka YGR191W aka G7572
Length:603
Molecular Weight:66006.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Histidine, Mn2+, Co 2+, Ni 2+, Zn 2+, Cu 2+

Cross database links:

Genevestigator: P06775
eggNOG: fuNOG08125
HEGENOM: HBG492579
DIP: DIP-5549N
RefSeq: NP_011707.1   
Entrez Gene ID: 853104   
Pfam: PF00324   
KEGG: sce:YGR191W   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005291 F:high affinity L-histidine transmembrane tra...
GO:0005515 F:protein binding
GO:0015817 P:histidine transport
GO:0006828 P:manganese ion transport
GO:0055085 P:transmembrane transport

References (5)

[1] “The histidine permease gene (HIP1) of Saccharomyces cerevisiae.”  Tanaka J.et.al.   3905514
[2] “The complete sequence of a 9037 bp DNA fragment of the right arm of Saccharomyces cerevisiae chromosome VII.”  Arroyo J.et.al.   7645350
[3] “The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.”  Tettelin H.et.al.   9169869
[4] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
[5] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MPRNPLKKEY WADVVDGFKP ATSPAFENEK ESTTFVTELT SKTDSAFPLS SKDSPGINQT 
61:	TNDITSSDRF RRNEDTEQED INNTNLSKDL SVRHLLTLAV GGAIGTGLYV NTGAALSTGG 
121:	PASLVIDWVI ISTCLFTVIN SLGELSAAFP VVGGFNVYSM RFIEPSFAFA VNLNYLAQWL 
181:	VLLPLELVAA SITIKYWNDK INSDAWVAIF YATIALANML DVKSFGETEF VLSMIKILSI 
241:	IGFTILGIVL SCGGGPHGGY IGGKYWHDPG AFVGHSSGTQ FKGLCSVFVT AAFSYSGIEM 
301:	TAVSAAESKN PRETIPKAAK RTFWLITASY VTILTLIGCL VPSNDPRLLN GSSSVDAASS 
361:	PLVIAIENGG IKGLPSLMNA IILIAVVSVA NSAVYACSRC MVAMAHIGNL PKFLNRVDKR 
421:	GRPMNAILLT LFFGLLSFVA ASDKQAEVFT WLSALSGLST IFCWMAINLS HIRFRQAMKV 
481:	QERSLDELPF ISQTGVKGSW YGFIVLFLVL IASFWTSLFP LGGSGASAES FFEGYLSFPI 
541:	LIVCYVGHKL YTRNWTLMVK LEDMDLDTGR KQVDLTLRRE EMRIERETLA KRSFVTRFLH 
601:	FWC