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2.A.3.10.11
Basic amino acid permease

Accession Number:P38971
Protein Name:Alp1 aka YNL270C aka N0660
Length:573
Molecular Weight:64014.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Basic Amino Acids

Cross database links:

Genevestigator: P38971
eggNOG: fuNOG04851
HEGENOM: HBG492579
RefSeq: NP_014129.1   
Entrez Gene ID: 855451   
Pfam: PF00324   
KEGG: sce:YNL270C   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015174 F:basic amino acid transmembrane transporter ...
GO:0015802 P:basic amino acid transport
GO:0055085 P:transmembrane transport

References (5)

[1] “APL1, a yeast gene encoding a putative permease for basic amino acids.”  Sychrova H.et.al.   7941748
[2] “The sequence of a 24,152 bp segment from the left arm of chromosome XIV from Saccharomyces cerevisiae between the BNI1 and the POL2 genes.”  Sen-Gupta M.et.al.   8740425
[3] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications.”  Philippsen P.et.al.   9169873
[4] “Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae.”  Regenberg B.et.al.   10654085
[5] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDETVNIQMS KEGQYEINSS SIIKEEEFVD EQYSGENVTK AITTERKVED DAAKETESSP 
61:	QERREVKRKL KQRHIGMIAL GGTIGTGLII GIGPPLAHAG PVGALISYLF MGTVIYSVTQ 
121:	SLGEMVTFIP VTSSFSVFAQ RFLSPALGAT NGYMYWLSWC FTFALELSVL GKVIQYWTEA 
181:	VPLAAWIVIF WCLLTSMNMF PVKYYGEFEF CIASIKVIAL LGFIIFSFCV VCGAGQSDGP 
241:	IGFRYWRNPG AWGPGIISSD KNEGRFLGWV SSLINAAFTY QGTELVGITA GEAANPRKAL 
301:	PRAIKKVVVR ILVFYILSLF FIGLLVPYND PKLDSDGIFV SSSPFMISIE NSGTKVLPDI 
361:	FNAVVLITIL SAGNSNVYIG SRVLYSLSKN SLAPRFLSNV TRGGVPYFSV LSTSVFGFLA 
421:	FLEVSAGSGK AFNWLLNITG VAGFFAWLLI SFSHIRFMQA IRKRGISRDD LPYKAQMMPF 
481:	LAYYASFFIA LIVLIQGFTA FAPTFQPIDF VAAYISIFLF LAIWLSFQVW FKCRLLWKLQ 
541:	DIDIDSDRRQ IEELVWIEPE CKTRWQRVWD VLS