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2.A.3.10.16
S-methylmethionine uptake permease, Mmp1

Accession Number:Q12372
Protein Name:Mmp1 aka YLL061w
Length:583
Molecular Weight:64218.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate S-Methylmethionine

Cross database links:

Genevestigator: Q12372
eggNOG: fuNOG08327
HEGENOM: HBG492579
DIP: DIP-8952N
RefSeq: NP_013039.1   
Entrez Gene ID: 850665   
Pfam: PF00324   
KEGG: sce:YLL061W   

Gene Ontology

GO:0005783 C:endoplasmic reticulum
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005515 F:protein binding
GO:0000100 F:S-methylmethionine transmembrane transporte...
GO:0015806 P:S-methylmethionine transport
GO:0055085 P:transmembrane transport

References (4)

[1] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.”  Johnston M.et.al.   9169871
[2] “Transport of sulfonium compounds. Characterization of the s-adenosylmethionine and s-methylmethionine permeases from the yeast Saccharomyces cerevisiae.”  Rouillon A.et.al.   10497160
[3] “Global analysis of protein localization in budding yeast.”  Huh W.-K.et.al.   14562095
[4] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDEFESTKLS KVQFSTSVLS TPSNEGNNLI HRFKNSFKRN DSPAIQEGLL YSELSEEEKI 
61:	QWDLANQPYK KVLDQRHLTM IAIGGTLGTG LFIGLGESLA SGPASLLIGF LLVGASMLCV 
121:	VQCGAELSCQ YPVSGSYALH ASRFIDPSVG FSIGINYLLM WLISYPSELV GCSLTISYWA 
181:	PSVNPAAWVA IAFVLSMLLN LFGARGFAES EFYMSIFKIV ALFIFIIIGI VLIAGGGPDS 
241:	TGYIGTKYWH DPGSFAVPVF KNLCNTFVSA AYSFSGTEMV VLTSTEARSV SSVSRAAKGT 
301:	FWRIIIFYIV TVIIIGCLVP YNDPRLISGS SSEDITASPF VIALSNTGAM GTRVSHFMNA 
361:	VILIAVFSVC NSCVYASSRL IQGLATAGQL PKICAYMDRN GRPLVGMAIC GAFGLLGFLV 
421:	VSKNQGTVFT WLFALCSISF FTTWFCICFC QVRFRMAMKA QGRSKDDIIY RSTLGIYGGI 
481:	FGCILNVLLV IGEIYVSAAP VGSPSSAANF FEYCMSIPIM IAVYIGHRIY RRDWRHWYIK 
541:	RMDIDLDSGH SLEDFEATKL ERDEDKKYVS SKPLYYRIYR FFC