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2.A.3.10.20
The high affinity basic amino acid (Arg, Lys, His) transporter, Can1 (Matijekova and Sychrova, 1997)

Accession Number:P43059
Protein Name:Lysine/arginine permease aka CAN1
Length:571
Molecular Weight:63317.00
Species:Candida albicans (Yeast) [5476]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Arginine, lysine, Histidine

Cross database links:

Pfam: PF00324   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015171 F:amino acid transmembrane transporter activity
GO:0006865 P:amino acid transport
GO:0055085 P:transmembrane transport

References (1)

[1] “CAN1, a gene encoding a permease for basic amino acids in Candida albicans.”  Sychorova H.et.al.   7725800

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPEDYEKYRM GSSNESHQKS VQPISSSISK SNKKTKHQTD FVQDSDIIEA SSINDEFGEV 
61:	KRDLKARHVS MIAIGGTIGT GLFISTGSLL HTTGPVMSLI SFLFVTTICF SVTQSLGEMA 
121:	TYIPISGSFA QFVTRWVSKS CGAANGWLYW FSWAVTFGLE LSVVGQVIQF WTDAVPLAAW 
181:	ISIFFVILTI FNFFPVKFYG EVEFWIASIK IIAVFGWIIY AFIMVCGAGK TGPVGFRYWR 
241:	NGYAWGDGIL VNNNGKYVAA FVSGLINSIF TFQGSELVAV TAGEASPRAL RSAIRKVMFR 
301:	ILVFYVLCML FMGLLVPYND PKLTQDGGFT RNSPFLIAME NSGTKVLPHI FNAVIVTTII 
361:	SAGNSNIYSG SRILYGLAQA GVAPKFFLRT NKGGVPFFAV AFTAAFGALG YLACSSQGNK 
421:	AFTWLLNITA TAGLISWGFI SVSHIRFMKT LQRRGISRDT LPFKAFFMPF SAYYGMVVCF 
481:	IVVLIQGFTV FWDFNASDFF TAYISVILFV VLWVGFHFFF YGFGKDSFKM SNILVPLDEC 
541:	DIDSGVRDIN DAEFDIPPPK NAWDKFWANV A