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2.A.3.10.27
Valine amino-acid permease (Branched-chain amino-acid permease 3)

Accession Number:P41815
Protein Name:Valine amino-acid permease
Length:604
Molecular Weight:67365.00
Species:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Valine

Cross database links:

Genevestigator: P41815
eggNOG: COG0833
HEGENOM: HOG000261848
DIP: DIP-7900N
Entrez Gene ID: 851616   
Pfam: PF00324   
KEGG: sce:YDR046C   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005739 C:mitochondrion
GO:0015171 F:amino acid transmembrane transporter activity

References (5)

[1] “Cloning and chromosomal organization of a gene encoding a putative amino-acid permease from Saccharomyces cerevisiae.”  Mai B.et.al.   8200527
[2] “The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.”  Jacq C.et.al.   9169867
[3] “Cysteine uptake by Saccharomyces cerevisiae is accomplished by multiple permeases.”  During-Olsen L.et.al.   10467005
[4] “Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae.”  Regenberg B.et.al.   10654085
[5] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSDPIVTSSK MEKSAEFEVT DSALYNNFNT STTASLTPEI KEHSEESRNG LVHRFVDSFR 
61:	RAESQRLEED NDLEDGTKSM KSNNHLKKSM KSRHVVMMSL GTGIGTGLLV ANAKGLSLAG 
121:	PGSLVIGYVM VSFVTYFMVQ AAGEMGVTYP TLPGNFNAYN SIFISKSFGF ATTWLFCIQW 
181:	LTVLPLELIT SSMTVKYWND TINADVFIVI FYVFLLFIHF FGVKAYGETE FIFNSCKILM 
241:	VAGFIILSVV INCGGAGVDG YIGGKYWRDP GSFAEGSGAT RFKGICYILV SAYFSFGGIE 
301:	LFVLSINEQS NPRKSTPVAA KRSVYRILII YLLTMILIGF NVPHNNDQLM GSGGSATHAS 
361:	PYVLAASIHK VRVIPHIINA VILISVISVA NSALYAAPRL MCSLAQQGYA PKFLNYIDRE 
421:	GRPLRALVVC SLVGVVGFVA CSPQEEQAFT WLAAIAGLSE LFTWSGIMLS HIRFRKAMKV 
481:	QGRSLDEVGY KANTGIWGSY YGVFFNMLVF MAQFWVALSP IGNGGKCDAQ AFFESYLAAP 
541:	LWIFMYVGYM VYKRDFTFLN PLDKIDLDFH RRVYDPEIMR QEDEENKERL KNSSIFVRVY 
601:	KFWC