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2.A.3.10.3
Proline permease

Accession Number:P15380
Protein Name:Put4 aka YOR348C aka O6345
Length:627
Molecular Weight:68788.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Proline

Cross database links:

Genevestigator: P15380
eggNOG: fuNOG04851
HEGENOM: HBG492579
DIP: DIP-1541N
RefSeq: NP_014993.1   
Entrez Gene ID: 854530   
Pfam: PF00324   
KEGG: sce:YOR348C   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015193 F:L-proline transmembrane transporter activity
GO:0005515 F:protein binding
GO:0019676 P:ammonia assimilation cycle
GO:0006562 P:proline catabolic process
GO:0015824 P:proline transport
GO:0055085 P:transmembrane transport

References (4)

[1] “Nucleotide sequence of the Saccharomyces cerevisiae PUT4 proline-permease-encoding gene: similarities between CAN1, HIP1 and PUT4 permeases.”  Vandenbol M.et.al.   2687114
[2] “Nucleotide sequence analysis of a 40 kb segment on the right arm of yeast chromosome XV reveals 18 open reading frames including a new pyruvate kinase and three homologues to chromosome I genes.”  Purnelle B.et.al.   8948102
[3] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.”  Dujon B.et.al.   9169874
[4] “Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae.”  Regenberg B.et.al.   10654085

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVNILPFHKN NRHSAGVVTC ADDVSGDGSG GDTKKEEDVV QVTESPSSGS RNNHRSDNEK 
61:	DDAIRMEKIS KNQSASSNGT IREDLIMDVD LEKSPSVDGD SEPHKLKQGL QSRHVQLIAL 
121:	GGAIGTGLLV GTSSTLHTCG PAGLFISYII ISAVIYPIMC ALGEMVCFLP GDGSDSAGST 
181:	ANLVTRYVDP SLGFATGWNY FYCYVILVAA ECTAASGVVE YWTTAVPKGV WITIFLCVVV 
241:	ILNFSAVKVY GESEFWFASI KILCIVGLII LSFILFWGGG PNHDRLGFRY WQHPGAFAHH 
301:	LTGGSLGNFT DIYTGIIKGA FAFILGPELV CMTSAECADQ RRNIAKASRR FVWRLIFFYV 
361:	LGTLAISVIV PYNDPTLVNA LAQGKPGAGS SPFVIGIQNA GIKVLPHIIN GCILTSAWSA 
421:	ANAFMFASTR SLLTMAQTGQ APKCLGRINK WGVPYVAVGV SFLCSCLAYL NVSSSTADVF 
481:	NWFSNISTIS GFLGWMCGCI AYLRFRKAIF YNGLYDRLPF KTWGQPYTVW FSLIVIGIIT 
541:	ITNGYAIFIP KYWRVADFIA AYITLPIFLV LWFGHKLYTR TWRQWWLPVS EIDVTTGLVE 
601:	IEEKSREIEE MRLPPTGFKD KFLDALL