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2.A.3.10.5
High affinity glutamine permease

Accession Number:P48813
Protein Name:Gnp1 aka YDR508C aka D9719.14
Length:663
Molecular Weight:73598.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Mitochondrion membrane1 / Multi-pass membrane protein2
Substrate Glutamine

Cross database links:

Genevestigator: P48813
eggNOG: fuNOG07978
HEGENOM: HBG492579
DIP: DIP-1616N
RefSeq: NP_010796.1   
Entrez Gene ID: 852121   
Pfam: PF00324   
KEGG: sce:YDR508C   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0031966 C:mitochondrial membrane
GO:0015193 F:L-proline transmembrane transporter activity
GO:0005515 F:protein binding
GO:0006865 P:amino acid transport
GO:0055085 P:transmembrane transport

References (12)

[1] “GNP1, the high-affinity glutamine permease of S. cerevisiae.”  Zhu X.et.al.   8660458
[2] “The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.”  Jacq C.et.al.   9169867
[3] “Cysteine uptake by Saccharomyces cerevisiae is accomplished by multiple permeases.”  During-Olsen L.et.al.   10467005
[4] “Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae.”  Regenberg B.et.al.   10654085
[5] “Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae.”  Ficarro S.B.et.al.   11875433
[6] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
[7] “A proteomics approach to understanding protein ubiquitination.”  Peng J.et.al.   12872131
[8] “The proteome of Saccharomyces cerevisiae mitochondria.”  Sickmann A.et.al.   14576278
[9] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258
[10] “Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.”  Li X.et.al.   17330950
[11] “Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases.”  Smolka M.B.et.al.   17563356
[12] “A multidimensional chromatography technology for in-depth phosphoproteome analysis.”  Albuquerque C.P.et.al.   18407956

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MTLGNRRHGR NNEGSSNMNM NRNDLDDVSH YEMKEIQPKE KQIGSIEPEN EVEYFEKTVE 
61:	KTIENMEYEG EHHASYLRRF IDSFRRAEGS HANSPDSSNS NGTTPISTKD SSSQLDNELN 
121:	RKSSYITVDG IKQSPQEQEQ KQENLKKSIK PRHTVMMSLG TGIGTGLLVG NSKVLNNAGP 
181:	GGLIIGYAIM GSCVYCIIQA CGELAVIYSD LIGGFNTYPL FLVDPALGFS VAWLFCLQWL 
241:	CVCPLELVTA SMTIKYWTTS VNPDVFVVIF YVLIVVINVF GAKGYAEADF FFNCCKILMI 
301:	VGFFILAIII DCGGAGTDGY IGSKYWRDPG AFRGDTPIQR FKGVVATFVT AAFAFGMSEQ 
361:	LAMTASEQSN PRKAIPSAAK KMIYRILFVF LASLTLVGFL VPYTSDQLLG AAGSATKASP 
421:	YVIAVSSHGV RVVPHFINAV ILLSVLSVAN GAFYTSSRIL MSLAKQGNAP KCFDYIDREG 
481:	RPAAAMLVSA LFGVIAFCAS SKKEEDVFTW LLAISGLSQL FTWITICLSH IRFRRAMKVQ 
541:	GRSLGEVGYK SQVGVWGSAY AVLMMVLALI AQFWVAIAPI GGGGKLSAQS FFENYLAMPI 
601:	WIALYIFYKV WKKDWSLFIP ADKVDLVSHR NIFDEELLKQ EDEEYKERLR NGPYWKRVLD 
661:	FWC