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2.A.3.10.6
Leu/Val/Ile amino acid permease

Accession Number:P38084
Protein Name:Bap2 aka YBR068C aka YBR0629
Length:609
Molecular Weight:67670.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Leucine, Valine, Isoleucine

Cross database links:

Genevestigator: P38084
eggNOG: fuNOG05379
HEGENOM: HBG492579
DIP: DIP-4910N
RefSeq: NP_009624.1   
Entrez Gene ID: 852360   
Pfam: PF00324   
KEGG: sce:YBR068C   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015171 F:amino acid transmembrane transporter activity
GO:0005515 F:protein binding
GO:0006865 P:amino acid transport
GO:0055085 P:transmembrane transport

References (9)

[1] “Complete DNA sequence of yeast chromosome II.”  Feldmann H.et.al.   7813418
[2] “BAP2, a gene encoding a permease for branched-chain amino acids in Saccharomyces cerevisiae.”  Grauslund M.et.al.   7495881
[3] “Cysteine uptake by Saccharomyces cerevisiae is accomplished by multiple permeases.”  During-Olsen L.et.al.   10467005
[4] “Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae.”  Regenberg B.et.al.   10654085
[5] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
[6] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258
[7] “Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.”  Li X.et.al.   17330950
[8] “Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases.”  Smolka M.B.et.al.   17563356
[9] “A multidimensional chromatography technology for in-depth phosphoproteome analysis.”  Albuquerque C.P.et.al.   18407956

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLSSEDFGSS GKKETSPDSI SIRSFSAGNN FQSSSSEKTY SKQKSGSDKL IHRFADSFKR 
61:	AEGSTTRTKQ INENTSDLED GVESITSDSK LKKSMKSRHV VMMSLGTGIG TGLLVANAKG 
121:	LHYGGPAALI IGYILVSFET YFMIQAAGEM AVTYPTLPAN FNAYSSIFIS KSFGFATVWL 
181:	YCFQWLTVLP LELITASMTI QFGNDKINPD IYILIFYVFL VFIHFFGVKA YGETEFIFNC 
241:	CKILMIAGFI ILSIVINCGG AGNDGYIGAT YWHNPGAFAG DTSIGRFKNV CYILVTAYFS 
301:	FGGMELFALS VQEQSNPRKS TPVAAKRSIY RIVVIYLLTM ILIGFNVPYN DDQLMGAGGS 
361:	ATHASPYVLA ASIHGVKIVP HIINAVILIS VVSVANSSLY AGPRLICSLA QQGYAPKFLD 
421:	YVDREGRPLR ALIVCCVFGV IAFVAASSKE EIVFTWLAAI AGLSELFTWT SIMLSHLRFR 
481:	QAMKVQGRSL DELGYKATTG IWGSIYGVFF NILVFVAQFW VALAPLGNGG KCDAESFFQN 
541:	YLAFPIWLAF YFGYMVYNRD FTLLNPLDKI DLDFHRRIYD PELMRQEDEE NKEKLRNMSL 
601:	MRKAYHFWC