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2.A.3.3.6
solute carrier family 7 (orphan transporter), member 4

Accession Number:O43246
Protein Name:Cationic amino acid transporter 4
Length:635
Molecular Weight:68268.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Unknown

Cross database links:

Genevestigator: O43246 O43246
eggNOG: COG0531 COG0531
HEGENOM: HOG000250623 HOG000250623
Entrez Gene ID: 6545   
Drugbank: Drugbank Link   
KEGG: hsa:6545    hsa:6545   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015174 F:basic amino acid transmembrane transporter activity
GO:0006520 P:cellular amino acid metabolic process

References (6)

[1] “The gene encoding a cationic amino acid transporter (SLC7A4) maps to the region deleted in the velocardiofacial syndrome.”  Sperandeo M.P.et.al.   9598310
[2] “A genome annotation-driven approach to cloning the human ORFeome.”  Collins J.E.et.al.   15461802
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “The gene encoding a cationic amino acid transporter (SLC7A4) maps to the region deleted in the velocardiofacial syndrome.”  Sperandeo M.P.et.al.   9598310
[5] “A genome annotation-driven approach to cloning the human ORFeome.”  Collins J.E.et.al.   15461802
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MARGLPTIAS LARLCQKLNR LKPLEDSTME TSLRRCLSTL DLTLLGVGGM VGSGLYVLTG 
61:	AVAKEVAGPA VLLSFGVAAV ASLLAALCYA EFGARVPRTG SAYLFTYVSM GELWAFLIGW 
121:	NVLLEYIIGG AAVARAWSGY LDSMFSHSIR NFTETHVGSW QVPLLGHYPD FLAAGIILLA 
181:	SAFVSCGARV SSWLNHTFSA ISLLVILFIV ILGFILAQPH NWSADEGGFA PFGFSGVMAG 
241:	TASCFYAFVG FDVIAASSEE AQNPRRSVPL AIAISLAIAA GAYILVSTVL TLMVPWHSLD 
301:	PDSALADAFY QRGYRWAGFI VAAGSICAMN TVLLSLLFSL PRIVYAMAAD GLFFQVFAHV 
361:	HPRTQVPVAG TLAFGLLTAF LALLLDLESL VQFLSLGTLL AYTFVATSII VLRFQKSSPP 
421:	SSPGPASPGP LTKQQSSFSD HLQLVGTVHA SVPEPGELKP ALRPYLGFLD GYSPGAVVTW 
481:	ALGVMLASAI TIGCVLVFGN STLHLPHWGY ILLLLLTSVM FLLSLLVLGA HQQQYREDLF 
541:	QIPMVPLIPA LSIVLNICLM LKLSYLTWVR FSIWLLMGLA VYFGYGIRHS KENQRELPGL 
601:	NSTHYVVFPR GSLEETVQAM QPPSQAPAQD PGHME