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2.A.30.1.16 Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4, KCC4) It has an anion selectivity of Cl- > Br- > PO₄^-3= I^- > SCN^- for KCC4) (Mercado et al. 2000).
Accession Number:	Q9Y666
Protein Name:	Solute carrier family 12 member 7
Length:	1083
Molecular Weight:	119106.00
Species:	Homo sapiens (Human) [9606]
Number of TMSs:	11
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate	chloride, bromide, iodide, isothiocyanato group

Entrez Gene ID:	10723
Pfam:	PF00324
KEGG:	hsa:10723
Gene Ontology GO:0005887 C:integral to plasma membrane GO:0015379 F:potassium:chloride symporter activity GO:0006884 P:cell volume homeostasis GO:0006813 P:potassium ion transport
References (9) [1] “Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family.” Mount D.B.et.al. 10347194 [2] “The DNA sequence and comparative analysis of human chromosome 5.” Schmutz J.et.al. 15372022 [3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [4] “Characterization of long cDNA clones from human adult spleen.” Hattori A.et.al. 11214971 [5] “The full-ORF clone resource of the German cDNA consortium.” Bechtel S.et.al. 17974005 [6] “Functional comparison of the K+-Cl- cotransporters KCC1 and KCC4.” Mercado A.et.al. 10913127 [7] “A quantitative atlas of mitotic phosphorylation.” Dephoure N.et.al. 18669648 [8] “Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.” Mayya V.et.al. 19690332 [9] “Similar Effects of all WNK3 Variants upon SLC12 Cotransporters.” Cruz-Rangel S.et.al. 21613606

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MPTNFTVVPV EAHADGGGDE TAERTEAPGT PEGPEPERPS PGDGNPRENS PFLNNVEVEQ 
61:	ESFFEGKNMA LFEEEMDSNP MVSSLLNKLA NYTNLSQGVV EHEEDEESRR REAKAPRMGT 
121:	FIGVYLPCLQ NILGVILFLR LTWIVGVAGV LESFLIVAMC CTCTMLTAIS MSAIATNGVV 
181:	PAGGSYYMIS RSLGPEFGGA VGLCFYLGTT FAGAMYILGT IEIFLTYISP GAAIFQAEAA 
241:	GGEAAAMLHN MRVYGTCTLV LMALVVFVGV KYVNKLALVF LACVVLSILA IYAGVIKSAF 
301:	DPPDIPVCLL GNRTLSRRSF DACVKAYGIH NNSATSALWG LFCNGSQPSA ACDEYFIQNN 
361:	VTEIQGIPGA ASGVFLENLW STYAHAGAFV EKKGVPSVPV AEESRASALP YVLTDIAASF 
421:	TLLVGIYFPS VTGIMAGSNR SGDLKDAQKS IPTGTILAIV TTSFIYLSCI VLFGACIEGV 
481:	VLRDKFGEAL QGNLVIGMLA WPSPWVIVIG SFFSTCGAGL QSLTGAPRLL QAIARDGIVP 
541:	FLQVFGHGKA NGEPTWALLL TVLICETGIL IASLDSVAPI LSMFFLMCYL FVNLACAVQT 
601:	LLRTPNWRPR FKFYHWTLSF LGMSLCLALM FICSWYYALS AMLIAGCIYK YIEYRGAEKE 
661:	WGDGIRGLSL NAARYALLRV EHGPPHTKNW RPQVLVMLNL DAEQAVKHPR LLSFTSQLKA 
721:	GKGLTIVGSV LEGTYLDKHM EAQRAEENIR SLMSTEKTKG FCQLVVSSSL RDGMSHLIQS 
781:	AGLGGLKHNT VLMAWPASWK QEDNPFSWKN FVDTVRDTTA AHQALLVAKN VDSFPQNQER 
841:	FGGGHIDVWW IVHDGGMLML LPFLLRQHKV WRKCRMRIFT VAQVDDNSIQ MKKDLQMFLY 
901:	HLRISAEVEV VEMVENDISA FTYERTLMME QRSQMLKQMQ LSKNEQEREA QLIHDRNTAS 
961:	HTAAAARTQA PPTPDKVQMT WTREKLIAEK YRSRDTSLSG FKDLFSMKPD QSNVRRMHTA 
1021:	VKLNGVVLNK SQDAQLVLLN MPGPPKNRQG DENYMEFLEV LTEGLNRVLL VRGGGREVIT 
1081:	IYS

2.A.30.1.16
Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4, KCC4) It has an anion selectivity of Cl- > Br- > PO₄^-3= I^- > SCN^- for KCC4) (Mercado et al. 2000).

Cross database links:

Gene Ontology

References (9)

External Searches:

Analyze:

2.A.30.1.16Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4, KCC4) It has an anion selectivity of Cl- > Br- > PO4-3 = I- > SCN- for KCC4) (Mercado et al. 2000).

Cross database links:

Gene Ontology

References (9)

External Searches:

Analyze:

2.A.30.1.16
Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4, KCC4) It has an anion selectivity of Cl- > Br- > PO₄^-3= I^- > SCN^- for KCC4) (Mercado et al. 2000).