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2.A.33.1.2
NhaA Na+,K+:H+ antiporter (Radchenko et al., 2006)

Accession Number:Q56725
Protein Name:Na+/H+ antiporter aka NhaA
Length:383
Molecular Weight:40433.00
Species:Vibrio parahaemolyticus [670]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Na+, K+, H+

Cross database links:

HEGENOM: HBG665619
RefSeq: NP_797607.1   
Entrez Gene ID: 1188733   
Pfam: PF06965   
BioCyc: VPAR223926:VP1228-MONOMER   
KEGG: vpa:VP1228   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015297 F:antiporter activity
GO:0015081 F:sodium ion transmembrane transporter activity
GO:0006885 P:regulation of pH
GO:0006814 P:sodium ion transport

References (2)

[1] “Properties and sequence of the NhaA Na+/H+ antiporter of Vibrio parahaemolyticus.”  Kuroda T.et.al.   7896730
[2] “Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae.”  Makino K.et.al.   12620739

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MNDVIRDFFK MESAGGILLV IAAAIAMTIA NSPLGETYQS LLHTYVFGMS VSHWINDGLM 
61:	AVFFLLIGLE VKRELLEGAL KSKETAIFPA IAAVGGMLAP ALIYVAFNAN DPEAISGWAI 
121:	PAATDIAFAL GIMALLGKRV PVSLKVFLLA LAIIDDLGVV VIIALFYTGD LSSMALLVGF 
181:	VMTGVLFMLN AKEVTKLTPY MIVGAILWFA VLKSGVHATL AGVVIGFAIP LKGKQGEHSP 
241:	LKHMEHALHP YVAFGILPLF AFANAGISLE GVSMSGLTSM LPLGIALGLL IGKPLGIFSF 
301:	SWAAVKLGVA KLPEGINFKH IFAVSVLCGI GFTMSIFISS LAFGNVSPEF DTYARLGILM 
361:	GSTTAAVLGY ALLHFSLPKK AQD