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2.A.33.1.5
Na+/H+ antiporter (Sodium/proton antiporter), NhaA

Accession Number:Q8G5R2
Protein Name:Na(+)/H(+) antiporter nhaA
Length:472
Molecular Weight:49613.00
Species:Bifidobacterium longum (strain NCC 2705) [206672]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Na+, H+

Cross database links:

eggNOG: COG3004
HEGENOM: HOG000218489
Entrez Gene ID: 1022440   
Pfam: PF06965   
KEGG: blo:BL0942   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015297 F:antiporter activity
GO:0006885 P:regulation of pH
GO:0006814 P:sodium ion transport

References (1)

[1] “The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract.”  Schell M.A.et.al.   12381787

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MATTAGAKKG LWSTIRRIAA SDRISGLIML GFALTGLVLA NLPATAHAFE TVAETHLFIP 
61:	YTNLDLPIGH WAQDGLLTIF FLTVGLELKQ ELTTGSLANP KAAAVPMLCA VGGMIAPPIL 
121:	FLAVTALFSQ IGPGEPGTLI LTTTGSSIPF SEMSHGWAVP TATDIAFSLA VLALFAKALP 
181:	GSIRAFLMTL ATVDDLLAII LIAVFFSSIN AWYWFIGIAV CAAIWAYLVR LKKVPWIAVG 
241:	IVGILAWIMM FEAGVHPTLA GVLVGLLTPS REMHGELSPR AERYANKLQP FSALLALPIF 
301:	ALFATGVHFE SMSPLLLASP LVIALIVALV VGKPLGIITT AWLSTHVGGL KMAKGLRVRD 
361:	MIPAAVACGI GFTVSFLIAS LAYKNAELSA EARFGVLVAS LIAAAISGVL LSRQSKRFEK 
421:	TAAAAAADEE DDESIDGDGI GQPSHTTEPT TPTEHPGTLA DGTASVEIDF RH