TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.33.1.6
Na+/H+ antiporter (Sodium/proton antiporter), NhaA

Accession Number:Q9S1X8
Protein Name:Na(+)/H(+) antiporter nhaA 1/4
Length:410
Molecular Weight:41975.00
Species:Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [100226]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Na+, H+

Cross database links:

eggNOG: COG3004
HEGENOM: HOG000218489
Entrez Gene ID: 1095436    1103270   
Pfam: PF06965   
KEGG: sco:SCO0015    sco:SCO7832   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015297 F:antiporter activity
GO:0006885 P:regulation of pH
GO:0006814 P:sodium ion transport

References (1)

[1] “Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).”  Bentley S.D.et.al.   12000953

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MSAPSRITAA LRSDAVGGSL LIGAAVIALI WANSPLSHSY EALRSFTFGP SALHLNLSVE 
61:	TWAADGLLAV FFFIVGNELK QELVHGELRD PRRAALPIAA ALGGVAVPAL VFLAFTLGSG 
121:	GEAAGGWGIP MATGIAFAVA VLAVVGRHLP TPLRTFLLTL ATVDDMSAVL VIAVACTSGI 
181:	NFTALALAAV GLAVFGYLQN GSGRAVARVR AMVPAWLLFV PLAAVVWALM HACGVHATIA 
241:	GVVMGLLMRT RPQGAERVSP SHRAEEVLRP FSAGIALPLF ALMSAGVSLA GAGGFVTSAI 
301:	TWNVLAGLLV GKVVGIFGGT WPTSRLTSAH LNPLLGWADI AGIAVLGGIG FTVSLPIAEL 
361:	SSTSQAHLTD AKGAILLAST TAALLAALLL GRRSRHHQRL ARQAAQQATT