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TCID	Name	Organismal Type	Example
2.A.36.1.1	Na⁺:H⁺ antiporter 1 (Nhe-1) (Regulated by Daxx (O35613)). An integral membrane protein that regulates intracellular pH and has a large N-terminal membrane domain of 12 transmembrane segments and an intracellular C-terminal regulatory domain (Reddy et al., 2008). The dimer catalyzes antiport crila 2NA⁺/2H⁺ stoichiometry (Fuster et al., 2008).	Animals	Nhe-1 of Rattus norvegicus
2.A.36.1.2	Na⁺:H⁺ antiporter 3 (Nhe-3). Regulated by Na⁺/H⁺ exchange regulatory cofactors (NHERF; O14745; TC #8.A.24.1.1) (Seidler et al., 2009).	Animals	Nhe-3 of Rattus norvegicus
2.A.36.1.3	Na⁺/K⁺:H⁺ antiporter, Nhe-7	Animals	Nhe7 of Homo sapiens
2.A.36.1.4	Cl^--dependent Na⁺:H⁺ antiporter (Nhe) (residues 1-375 are identical to Nhe-1 [TC #2.A.36.1.1]).	Animals	Nhe of Rattus norvegicus
2.A.36.1.5	Na⁺/K⁺:H⁺ antiporter, NHX2	Plants	NHX2 of Lycopersicon esculentum (CAC83608)
2.A.36.1.6	Zebrafish Na⁺:H⁺ antiporter NheC (Yan et al., 2007) (most similar to TC# 2.A.36.1.2, 48% identical)	Animals	NheC of Danio rerio (A3KPJ8)
2.A.36.1.7	The basolateral intestinal Na⁺/H⁺ antiporter PBO-4 (Beg et al., 2008)	Animals	PBO-4 of Caenorhabditis elegans (Q21386)
2.A.36.1.8	Na⁺/H⁺ exchanger, Nhx-2 (Pfeiffer et al., 2008)	Animal	Nhx-2 of Caenorhabditis elegans (Q09432)
2.A.36.1.9	Human Na⁺/H⁺ Exchanger, NHE-8 or SLC9A8. Functions in intracellular pH homeostasis, cell volume regulation, and electroneutral NaCl absorption in epithelia.	Animal	NHE-8 of Homo sapiens (Q9Y2E8)
2.A.36.1.10	Basal membrane Nhe3	Animals	Nhe3 of Aedes aegypti (Q17L17)
2.A.36.1.11	Na⁺:H⁺ exchanger (NHE), SLC9A8. Functions in intracellular pH homeostasis, cell volume regulation, and electroneutral NaCl absorption in epithelia.	Animals	SLC9A8 (612730) of Homo sapiens (Q9Y2E8)
2.A.36.2.1	Na⁺:H⁺ antiporter; (vacuolar/endosomal Na⁺ tolerance protein)	Yeast; plants	NHX1 (YDR456w) of Saccharomyces cerevisiae
2.A.36.3.1	Putative antiporter (function unknown)	Bacteria	YjcE of E. coli
2.A.36.3.2	Na⁺, K⁺, Li⁺, Rb⁺:H⁺ antiporter, YvgP	Bacteria	YvgP of Bacillus subtilis (CAB15347)
2.A.36.4.1	[Na⁺ or K⁺]:H⁺ antiporter Nha1	Yeast	Nha1 (YLR138w) of Saccharomyces cerevisiae
2.A.36.4.2	Na⁺:H⁺ antiporter, Nha2	Yeast	Nha2 of Zygosaccharomyces rouxii
2.A.36.4.3	Na⁺:H⁺ antiporter, Nha1	Yeast	Nha1 of Schizosaccharomyces pombe
2.A.36.4.4	The K⁺, Rb⁺ and other alkali metal cation efflux porter, Cnh1 (Kinclova-Zimmermannova and Sychrova, 2007). Transports Na⁺, K⁺, Li⁺ and Rb⁺ in several Candida species. Confers tolerance to high salt concentrations (Krauke and Sychrova 2008).	Yeast	Cnh1 of Candida albicans (Q9P937)
2.A.36.5.1	Low-affinity Na⁺ (K⁺, Li⁺ or Cs⁺):H⁺ antiporter, Nhx1	Plants	Nhx1 of Arabidopsis thaliana
2.A.36.6.1	Putative Na⁺:H⁺ antiporter, Nhe2	Archaea	The AF0846 gene (Nhe2) of Archaeoglobus fulgidus
2.A.36.6.2	Na⁺ (Li⁺):H⁺ antiporter NhaG	Bacteria	NhaG of Bacillus subtilis ATCC9372
2.A.36.6.3	K⁺:H⁺ antiporter, KhaP2 (NhaP2). Participates in volume control under low osmorality conditions (Radchenko et al., 2006; Resch et al., 2010)	Bacteria	KhaP2 of Vibrio parahaemolyticus (Q87KV8)
2.A.36.6.4	The K⁺(NH₄⁺):H⁺ antiporter, NhaP (confers alkali resistance for alkaline pH homeostasis) (Wei et al., 2007)	Bacteria	NhaP of Alkalimonas amylolytica (Q0ZAH6)
2.A.36.6.5	K⁺:H⁺ antiporter NhaP2 (catalyzes K⁺:H⁺ and possibly K⁺:Li⁺ exchange; Resch et al., 2010). (84% identical to 2.A.36.6.3)	Bacteria	NhaP2 of Vibrio cholerae (Q9KNM9)
2.A.36.7.1	ApNhaP: a Na⁺:H⁺ antiporter at pH 5-9; a Ca²⁺:H⁺ antiporter at alkaline pH (not an Li:H⁺ antiporter)	Cyanobacteria	ApNhaP of Aphanothece halophytica
2.A.36.7.2	Low affinity (Km=8 mM) Na⁺(Li⁺):H⁺ antiporter, NhaS1	Bacteria	NhaS1 of Synechocystis sp. PCC6803
2.A.36.7.3	Li⁺/H⁺ antiporter, AtNHX8 (An et al., 2007)	Plants	NHX8 of Arabidopsis thaliana (Q3YL57)
2.A.36.8.1	The Na⁺/Li⁺:H⁺ antiporter, Nha2. Also catalyzes Na⁺:Li⁺ antiport; contributes to salt homeostasis; correlates with heritable hypertension (Xiang et al., 2007).	Animals	Nha2 of Homo sapiens (Q86UD5)