TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameOrganismal TypeExample
2.A.39.1.1









Cytosine permease
Bacteria
CodB of E. coli (P0AA82)
2.A.39.1.2









The putative hydroxymethylpyrimidine transporter, CytX (Rodionov et al. 2002)

Bacteria

CytX of Pseudomonas putida (B1JAG2)
2.A.39.1.3









The putative hydroxymethylpyrimidine porter, CytX (Rodionov et al., 2002

Proteobacteria, Fimicutes, Archaea

CytX of Neisseria meningitidis (A1KWE6)
2.A.39.1.4









Putative nucleobase transporter

Firmicute

Putative nucleobase transporter of Alicyclobacillus acidocaldarius (F8IKT4)
2.A.39.1.5









Putative purine-cytosine permease yxlA
Bacilli
yxlA of Bacillus subtilis
2.A.39.1.6









Actinobacteria

2.A.39.1.7









Actinobacteria

2.A.39.2.1









Cytosine-purine permease
Yeast
Fcy2 of Saccharomyces cerevisiae (P17064)
2.A.39.2.2









The vitamin B6:H+ symporter, Tpn1 (pyridoxine, pyridoxal and pyridoxamine are substrates) (Stolz and Vielreicher, 2003)
Yeast
Tpn1 of Saccharomyces cerevisiae (P53099)
2.A.39.2.3









The hypoxanthine/adenine/guanine (purine) transporter, Fcy21 (Goudela et al., 2006)
Yeast
Fcy21 of Candida albicans (Q708J7)
2.A.39.2.4









The cytosine-purine-scavenging protein, FcyB (low capacity, high affinity; 45% identical and maybe orthologous to the yeast purine-cytosine protein (2.A.39.2.3) (Vlanti and Diallinas 2008).  Substrate docking and mutational analyses have revealed residues essential for specificity and function (Krypotou et al. 2012).

Fungi

FycB of Aspergillus nidulans (B1PXD0)
2.A.39.3.1









Allantoin permease
Yeast
Dal4 of Saccharomyces cerevisiae
2.A.39.3.2









Uracil/uridine permease
Yeast
Fur4 of Saccharomyces cerevisiae
2.A.39.3.3









Uridine (nucleoside; fluorouridine; not uracil or allantoin) permease, Fui1 (Uridine:H+ (1:1) symporter) (inhibited by analogues with modifications at positions C5') (Zhang et al., 2006)
Yeast
Fui1 (YBL042; YBC2) of Saccharomyces cerevisiae
2.A.39.3.4









Allantoin permease
Bacteria
PucI (YwoE) of Bacillus subtilis
2.A.39.3.5









The probable hydantoin permease, HyuP (most similar to the hydantoin transporter of Microbacterium liquefaciens; Suzuki and Henderson, 2006)
Bacteria
HyuP of Arthrobacter aurescens (Q9F467)
2.A.39.3.6









The benzyl-hydantoin:cation symporter-1, Mhp1.  The 3-d structures in the open and closed states (2.85 Å resolution) are known (Weyand et al., 2008). (84% identical to 2.A.39.3.5)

Bacteria

Mhp1 of Microbacterium liguefaciens
(2JLN_A) (210060745)
2.A.39.3.7









Uracil permease
Yeast
Fur4 of Schizosaccharomyces pombe
2.A.39.3.8









Allantoin permease; encoded in an operon with allantoinase and other degradative enzymes (Moraes and Reithmeier 2012).

Bacteria

YbbW of Escherichia coli
2.A.39.3.9









NCS-1 homologue of unknown function and of 652 aas with 14 TMSs in a 2 + 2 + 2... arrangment.

Red Algae

NCS-1 homologue of Galdieria sulphuraria
2.A.39.4.1









Thiamine permease, Thi10
Yeast
Thi10 of Saccharomyces cerevisiae
2.A.39.4.2









The nicotinamide riboside transporter, Nrt1 (Belenky et al., 2008)
Yeast
Nrt1 of Saccharomyces cerevisiae (Q08485)
2.A.39.5.1









The putative mannitol porter, MtlP (Rodionov et al. 2010).

Proteobacteria

MtlP of Shewanella frigidimarina (Q082R8)