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2.A.39.3.6
The benzyl-hydantoin:cation symporter-1, Mhp1 (84% identical to 2.A.39.3.5).  The 3-d structures in the open and closed states (2.85 Å resolution) are known (Weyand et al., 2008). Models of the ion-coupled coonformational cycle have been proposed (Kazmier et al. 2014).

Accession Number:D6R8X8
Protein Name:Hydantoin transport protein
Length:501
Molecular Weight:54581.00
Species:Microbacterium liquefaciens [33918]
Number of TMSs:12
Substrate Benzyl-hydantoin, cations, Nucleobases

Cross database links:

Pfam: PF02133   

Gene Ontology

GO:0016020 C:membrane
GO:0015205 F:nucleobase transmembrane transporter activity

References (1)

[1] “Molecular basis of alternating access membrane transport by the sodium-hydantoin transporter Mhp1.”  Shimamura T.et.al.   20413494
Structure:
2JLN   2X79   4D1A   4D1B   4D1C   4D1D     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNSTPIEEAR SLLNPSNAPT RYAERSVGPF SLAAIWFAMA IQVAIFIAAG QMTSSFQVWQ 
61:	VIVAIAAGCT IAVILLFFTQ SAAIRWGINF TVAARMPFGI RGSLIPITLK ALLSLFWFGF 
121:	QTWLGALALD EITRLLTGFT NLPLWIVIFG AIQVVTTFYG ITFIRWMNVF ASPVLLAMGV 
181:	YMVYLMLDGA DVSLGEVMSM GGENPGMPFS TAIMIFVGGW IAVVVSIHDI VKECKVDPNA 
241:	SREGQTKADA RYATAQWLGM VPASIIFGFI GAASMVLVGE WNPVIAITEV VGGVSIPMAI 
301:	LFQVFVLLAT WSTNPAANLL SPAYTLCSTF PRVFTFKTGV IVSAVVGLLM MPWQFAGVLN 
361:	TFLNLLASAL GPLAGIMISD YFLVRRRRIS LHDLYRTKGI YTYWRGVNWV ALAVYAVALA 
421:	VSFLTPDLMF VTGLIAALLL HIPAMRWVAK TFPLFSEAES RNEDYLRPIG PVAPADESAT 
481:	ANTKEQNQPA GGRGSHHHHH H